{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:39:29Z","timestamp":1764679169308,"version":"3.46.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatoblastoma is an embryonal tumor originating from hepatocyte precursors. Surgical resection is the primary treatment. Unresectable cases are treated with chemotherapy combined with liver transplantation. Patients with suboptimal chemotherapy response face limited therapeutic choices. Trans\u2010arterial radioembolization (TARE), trans\u2010arterial chemoembolization (TACE), and bland trans\u2010arterial embolization (TAE) are therapeutic radiologic techniques that preferentially utilize blood supply for liver tumors to deliver microspheres to the tumor. These radiologic techniques used in pediatrics are limited to relapsed diseases or for palliation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We describe the case of the youngest patient with hepatoblastoma to undergo TARE\u2010Y90 and the first pediatric patient to undergo TAE as a bridge to liver transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 12\u2010month\u2010old boy, born prematurely at 25\u2009weeks' gestation, was found to have PRETEXT III, intermediate\u2010risk, non\u2010metastatic, unresectable hepatoblastoma. His initial alpha\u2010fetoprotein (AFP) was elevated to 2,140,000\u2009ng\/mL. Systemic chemotherapy had minimal response, and escalation of chemotherapy was unsuccessful, raising concern for chemotherapy resistance. After multidisciplinary discussion, he underwent TARE\u2010Y90 with tumor response by imaging and improved AFP. However, his disease remained unresectable. TAE was performed twice as a bridge to liver transplant, followed by another chemotherapy cycle to minimize metastasis. Both procedures had minimal complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case represents the successful use of TARE and TAE for chemotherapy\u2010resistant hepatoblastoma to reduce tumor burden and to allow for curative liver transplant in a pediatric patient. Short\u2010term outcomes are promising as he underwent cadaveric liver transplantation and continues to do well without evidence of recurrence, 2\u2009years off therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70121","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T01:05:18Z","timestamp":1750813518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Use of Bland Trans\u2010Arterial Embolization for Hepatoblastoma: A Case Report"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8201-3827","authenticated-orcid":false,"given":"Dan","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology\/Oncology University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Vera","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sylvester Comprehensive Cancer Center  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong Bin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology\/Oncology University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel S.","family":"Kronenfeld","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology\/Oncology University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyson","family":"Trillo","sequence":"additional","affiliation":[{"name":"Johns Hopkins all Children's Hospital, St Petersburg, Florida, Cancer and Blood Disorders Institute  St Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-3167","authenticated-orcid":false,"given":"Taumoha","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology\/Oncology University of Utah\/Primary Children's Hospital  Salt Lake City Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akin","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida 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