{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T09:40:44Z","timestamp":1762940444893,"version":"3.45.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence of eosinophilic esophagitis (EoE) is up to 100 times greater in the liver transplant (LT) population than the general population. The purpose of this study was to identify differences between children who underwent LT and developed EoE and those who did not develop EoE. Identifying differences may permit earlier detection and treatment of EoE in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective, cross\u2010sectional single\u2010center study of children who underwent LT between 2007 and 2021 to identify patients who developed EoE compared to those who did not develop EoE following LT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, the prevalence of EoE in patients post LT is 8% and 13% in those undergoing esophagogastroduodenoscopy (EGD) for gastrointestinal (GI) symptoms post LT. Of 159 patients who underwent LT, 25% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) had GI symptoms necessitating EGD. Of these, 33% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913) were diagnosed with EoE (EoE\u2010LT) and 67% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927) did not have EoE (non\u2010EoE\u2010LT). EoE\u2010LT patients had a longer time from transplant to their first EGD compared to non\u2010EoE\u2010LT (2.93 vs. 0.90\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). EoE\u2010LT patients were more likely to have other allergic disorders (77% vs. 30%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), peripheral eosinophilia (62% vs. 11%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), or more feeding difficulties (62% vs. 11%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) than non\u2010EoE\u2010LT. Non\u2010EoE\u2010LT patients were more likely to undergo esophagogastroduodenoscopy (EGD) for gastrointestinal bleeding than EoE\u2010LT (30% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Among the EoE\u2010LT patients who underwent follow\u2010up EGD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), half were in histologic remission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The presence of feeding difficulties, allergic disorders, or peripheral eosinophilia in children who have undergone LT should raise suspicion for EoE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70181","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T13:30:46Z","timestamp":1758202246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophilic Esophagitis in a Large Cohort of Pediatric Liver Transplant Recipients"],"prefix":"10.1111","volume":"29","author":[{"given":"Melissa","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Section of Pediatric Gastroenterology, Hepatology and Nutrition Digestive Health Institute, Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxing","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Colorado School of Medicine  Colorado Aurora USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Section of Pediatric Gastroenterology, Hepatology and Nutrition Digestive Health Institute, Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn T.","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Section of Pediatric Gastroenterology, Hepatology and Nutrition Digestive Health Institute, Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikha S.","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Section of Pediatric Gastroenterology, Hepatology and Nutrition Digestive Health Institute, Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-8587","authenticated-orcid":false,"given":"Nathalie","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Section of Pediatric Gastroenterology, Hepatology and Nutrition Digestive Health Institute, Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.06.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.067"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17845"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.01063.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16349"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00867.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2012.01670.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003344"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.11.026"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00542.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000934"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000142"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.08.050"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1397-3142.2003.00116.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12143"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.07.041"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S274524"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.039"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.014"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13281"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T09:37:03Z","timestamp":1762940223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/petr.70181"],"URL":"https:\/\/doi.org\/10.1111\/petr.70181","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2025,9,18]]},"assertion":[{"value":"2025-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70181"}}