{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T17:09:35Z","timestamp":1766336975363,"version":"3.48.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder that leads to systemic oxalosis and end\u2010stage renal disease (ESRD). Before the advent of siRNA therapy, liver transplantation, often combined with kidney transplantation, was the only definitive treatment.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective review of eight pediatric patients with PH1 who underwent liver transplantation at a single tertiary care institution between 1998 and 2018. Clinical records were reviewed to extract data on transplant strategy, timing and modality of dialysis, surgical technique, and long\u2010term outcomes. Histopathological and imaging data were used to assess systemic oxalate deposition.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Five patients underwent sequential liver\u2010kidney transplantation (seqLKT), one received preemptive liver transplantation, and two received kidney transplantation prior to PH1 diagnosis. To reduce systemic oxalate burden, seqLKT patients received intensive dialysis bridging. Following an early case of hepatic artery thrombosis, arterial conduit reconstruction to the aorta was employed in subsequent cases to optimize hepatic inflow. Oxalate deposition in arterial walls, retina, or bone was documented in three patients. At a median follow\u2010up of 7.5\u2009years, seven of eight patients were alive with stable hepatic and renal graft function.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This case series illustrates the surgical complexity and multidisciplinary coordination required in pediatric PH1 management and supports the role of seqLKT with conduit\u2010based hepatic artery reconstruction and intensive dialysis bridging as effective approaches in selected patients, particularly in settings without access to gene\u2010targeted therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/petr.70225","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T04:09:40Z","timestamp":1763179780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Management of Pediatric Primary Hyperoxaluria Type 1: An Eight\u2010Patient Case Series in the Pre\u2010\n siRNA<\/scp>\n Era"],"prefix":"10.1111","volume":"29","author":[{"given":"Gal","family":"Finer","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Feinberg School of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre N.","family":"Darani","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Children's Hospital at Montefiore, Albert Einstein College of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew G.","family":"Switalski","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Melin\u2010Aldana","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA"},{"name":"Division of Pathology Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3076-2244","authenticated-orcid":false,"given":"Riccardo","family":"Superina","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois USA"},{"name":"Division of Transplant Surgery Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1007\/s00467\u2010022\u201005613\u20102"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1007\/s00240\u2010018\u20101093\u20103"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1053\/j.ajkd.2021.07.018"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1038\/s41598\u2010022\u201019584\u20109"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.3390\/ijms21103608"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1093\/ckj\/sfab217"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1016\/j.ekir.2020.09.022"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1016\/s0140\u20106736(89)92423\u20109"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1093\/ndt\/5.5.332"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1007\/s00467\u2010021\u201005043\u20106"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1186\/s12876\u2010020\u201001349\u20101"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1007\/s00467\u2010024\u201006328\u20102"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1038\/s41581\u2010022\u201000661\u20101"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1111\/ajt.16732"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T17:07:29Z","timestamp":1766336849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/petr.70225"],"URL":"https:\/\/doi.org\/10.1111\/petr.70225","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"2025-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70225"}}