{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:44:23Z","timestamp":1790876663804,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Despite the known impact of steroid therapy on growth after kidney transplantation (KTx), steroids remain widely used in pediatric KTx recipients. Evidence on the effect on linear growth at minimal doses of steroids (6\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      or 0.2\u2009mg\/kg\/day) is limited. This study evaluated whether low doses of steroid therapy are associated with post\u2010transplant growth failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Single\u2010center retrospective cohort study. In total, 44 pediatric KTx recipients from 2005 to 2024 were collected. Differences in\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010Score and height before 6\u2009months and after 6 and 12\u2009months of KTx were assessed using Friedman rank tests. Linear mixed models were used to analyze the longitudinal effect of steroid therapy on growth outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age at KTx was 11\u2009years (SD\u2009\u00b1\u20093.8). Median prednisolone doses at 3 and 6\u2009months after KTx were 0.23 (p25\u201375: 0.18\u20130.41) and 0.21\u2009mg\/k\/day (0.14\u20130.28), respectively. The mean\u2010height\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score improved from \u22122.35 (SD\u2009\u00b1\u20091.30) to 1.82 (SD\u2009\u00b1\u20091.23) one year post\u2010KTx. The percentage of patients with short stature (height\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score\u2009\u2264\u2009\u22122SD) decreased from 65.1% at baseline (KTx) to 54.8% and 52.3% after 6 and 12\u2009months, respectively. In multivariable analysis, time follow\u2010up and age at KTx were associated with post\u2010transplant growth. Steroid therapy shows a trend to reduce body height, but the interaction was not significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This single\u2010center study found that pediatric KTx recipients receiving low\u2010dose steroid therapy showed post\u2010transplant improvements in height and\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores. Notably, the use of low\u2010dose steroids did not significantly impair growth, although a slight downward trend in\n                      <jats:italic>Z<\/jats:italic>\n                      scores was noted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70251","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:48:42Z","timestamp":1766389722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Minimal Steroid Doses on Post\u2010Transplant Growth in Pediatric Kidney Recipients, a Retrospective Observational Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Carolina Lucia","family":"Ochoa\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Pediatric Department University of Antioquia  Medell\u00edn Colombia"},{"name":"Clinica Somer  Rionegro Colombia"},{"name":"Pediatric Department Universidad Remington  Medellin Colombia"},{"name":"Research Group in Clinical Epidemiology and Pediatrics Hospital Pablo Tobon Uribe  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Villegas\u2010Arbel\u00e1ez","sequence":"additional","affiliation":[{"name":"Research Group in Clinical Epidemiology and Pediatrics Hospital Pablo Tobon Uribe  Medell\u00edn Colombia"},{"name":"Institut de Recerca Sant Pau  Barcelona Espa\u00f1a"},{"name":"Faculty of Medicine Universidad CES  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Camilo","family":"Pel\u00e1ez\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Pontificia Bolivariana University  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Serna\u2010Campuzano","sequence":"additional","affiliation":[{"name":"Research Group in Clinical Epidemiology and Pediatrics Hospital Pablo Tobon Uribe  Medell\u00edn Colombia"},{"name":"Hospital San Vicente de Paul  Rionegro Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Fernanda","family":"Rojas\u2010Rosas","sequence":"additional","affiliation":[{"name":"Pediatric Department Universidad Remington  Medellin Colombia"},{"name":"Research Group in Clinical Epidemiology and Pediatrics Hospital Pablo Tobon Uribe  Medell\u00edn Colombia"},{"name":"Hospital General de Medellin  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-8295","authenticated-orcid":false,"given":"Lina Maria","family":"Serna\u2010Higuita","sequence":"additional","affiliation":[{"name":"Pediatric Department University of Antioquia  Medell\u00edn Colombia"},{"name":"Research Group in Clinical Epidemiology and Pediatrics Hospital Pablo Tobon Uribe  Medell\u00edn Colombia"},{"name":"University Hospital T\u00fcbingen  Tubingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina","family":"Isaza\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Research Group in Clinical Epidemiology and Pediatrics Hospital Pablo Tobon Uribe  Medell\u00edn Colombia"},{"name":"Pontificia Bolivariana University  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-04922-2"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00890113"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195604052541402"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001320"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000347024"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0161-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14878"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2002.01084.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02180314"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2003.00068.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00805.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00356.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045780"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3761"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13989"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.043497"},{"issue":"3","key":"e_1_2_13_18_1","first-page":"232","article-title":"WHO Child Growth Standards for Children 0\u20105\u2009Years. 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