{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:57:52Z","timestamp":1769709472892,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>BK virus\u2010associated hemorrhagic cystitis (BKV\u2010HC) still remains a life\u2010threatening complication after Hematopoietic Stem Cell transplantation (HSCT). In this study, we analyzed a possible nosocomial transmission of BK virus (BKV) in a pediatric HSCT clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All the information of 131 patients who had HSCT in Akdeniz University Hospital pediatric HSCT clinic between July 2019 and July 2022 was screened for BKV\u2010HC. Twenty\u2010six patients developed BKV\u2010HC and 21 of them were related to the nosocomial transmission. Phylogenetic investigation was conducted on a total of 19 patients, comprising 15 pediatric cases believed to be associated with nosocomial transmission. All the patients had BKV DNA positivity in their urine samples and 17 of them also had BKV\u2010HC. A region approximately 677\u2009bp in length was sequenced and after alignment, phylogenetic analysis was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>In phylogenetic analysis, three clusters including 11, 5, and 3 patients having identical sequences were formed. To our knowledge, this is the biggest BKV\u2010HC nosocomial transmission seen among HSCT patients. Nosocomial BKV transmission affecting HSCT patients was proven with phylogenetic and statistical analysis. Furthermore, this study presented a novel finding, describing two HSCT patients affected by nosocomial transmission, evidenced by the presence of BKV\u2010DNA in their urine samples, who had not developed HC. This observation marks the first documented instance of such cases within the context of nosocomial transmission of BKV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70252","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:01:20Z","timestamp":1766390480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The First Phylogenetically Confirmed Hemorrhagic Cystitis Outbreak Among Pediatric Hematopoietic Stem Cell Transplant Recipients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4904-6987","authenticated-orcid":false,"given":"Tugba Nukte","family":"Tezel","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Medical Microbiology Department, Division of Virology Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-137X","authenticated-orcid":false,"given":"Derya","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical Microbiology Department, Division of Virology Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9466-1832","authenticated-orcid":false,"given":"Nazli","family":"Gurkan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical Microbiology Department, Division of Virology Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-7188","authenticated-orcid":false,"given":"Funda Tayfun","family":"Kupesiz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pediatric Hematology\u2010Oncology Department Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-5567","authenticated-orcid":false,"given":"Alphan","family":"Kupesiz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pediatric Hematology\u2010Oncology Department Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5186-1092","authenticated-orcid":false,"given":"Ugur","family":"Bilge","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biostatistics and Medical Informatics Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-9182","authenticated-orcid":false,"given":"Esvet","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Akdeniz University Faculty of Medicine, Medical Microbiology Department, Division of Immunology  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-0130","authenticated-orcid":false,"given":"Dilek","family":"Colak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical Microbiology Department, Division of Virology Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-1382","authenticated-orcid":false,"given":"Orhan Kemal","family":"Yucel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hematology\u2010Oncology Department Akdeniz University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206273"},{"key":"e_1_2_8_3_1","first-page":"42","article-title":"Occurrence and Significance of Papovaviruses BK and JC in the Urine","volume":"36","author":"Arthur R. 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