{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:45:39Z","timestamp":1773006339679,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This pilot study evaluated the feasibility of integrating an immunosuppressant area under the concentration\u2010time curve (AUC) monitoring for tacrolimus and mycophenolic acid (MPA) into pediatric kidney transplantation care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Dedicated test codes, an AUC requisition form, and a coordinated laboratory sampling process were established for tacrolimus and MPA AUC. AUC was calculated using the ISBA 3.0 Bayesian pharmacokinetic platform. AUC results were correlated with doses, trough concentrations (C\n                      <jats:sub>0<\/jats:sub>\n                      ), 3\u2009h post\u2010dose concentrations (C\n                      <jats:sub>3h<\/jats:sub>\n                      ), and clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The AUC protocol was successfully integrated into the routine clinical workflow. Tacrolimus AUC showed correlations with dose (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.85) and C\n                      <jats:sub>0<\/jats:sub>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.82); similarly, MPA AUC showed correlation with dose (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.61) and C\n                      <jats:sub>3h<\/jats:sub>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.65). Of the 21 Tacrolimus AUC measurements, 76% were within the target range, and 24% were below the range. For MPA AUC measurements, 65% (13\/20) were within the target range, 5% (1\/20) were below the range, and 30% (6\/20) were above the range. Following individual AUC measurements, the tacrolimus dose was adjusted after 43% (9\/21) of measurements, and the mycophenolate mofetil (MMF) dose was adjusted after 50% (10\/20) of measurements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This AUC pilot study demonstrated the feasibility of integrating AUC\u2010guided monitoring into the routine management of pediatric kidney transplant recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70274","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:03:21Z","timestamp":1770725001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and Preliminary Outcomes of Area Under the Concentration\u2010Time Curve (\n                    <scp>AUC<\/scp>\n                    )\u2010Guided Tacrolimus and Mycophenolate Dosing in Pediatric Kidney Transplant Recipients"],"prefix":"10.1111","volume":"30","author":[{"given":"Song","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Saskatchewan Health Authority  Saskatoon Saskatchewan Canada"},{"name":"University of Saskatchewan College of Medicine  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramath","family":"Kakodkar","sequence":"additional","affiliation":[{"name":"University of Saskatchewan College of Medicine  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Saskatchewan College of Medicine  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of 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Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-5062","authenticated-orcid":false,"given":"Fang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Saskatchewan Health Authority  Saskatoon Saskatchewan Canada"},{"name":"University of Saskatchewan College of Medicine  Saskatoon Saskatchewan Canada"},{"name":"Department of Pathology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"S1","article-title":"KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients","volume":"9","author":"Kidney Disease: Improving Global Outcomes Transplant Work G","year":"2009","journal-title":"American Journal of 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