{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:02:57Z","timestamp":1789653777662,"version":"4.0.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the clinical features and outcomes of early laparoscopic appendectomy in pediatric patients who developed acute appendicitis following hematopoietic stem cell transplantation (HSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, single\u2010center study included 10 pediatric patients diagnosed with acute appendicitis after undergoing allogeneic HSCT between 2015 and 2025. Demographics, laboratory values, imaging findings, surgical timing, and outcomes were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 737 pediatric HSCT recipients, 10 patients (1.4%) developed acute appendicitis. The median age was 13\u2009years (range: 4\u201316), and 80% were male. Nine patients had a diagnosis of acute lymphoblastic leukemia and one had aplastic anemia. Appendicitis was diagnosed at a median of 23.5\u2009days post\u2010transplant. Half the patients were severely neutropenic (Absolute neutrophil count\u2009=\u20090) at the time of diagnosis. The most common presenting symptoms were abdominal pain (80%), vomiting (50%), and fever (40%). C\u2010reactive protein was elevated in all cases (median: 61\u2009mg\/L). While 40% of the cases were diagnosed by ultrasonography, 60% required computed tomography. All patients underwent early laparoscopic appendectomy within 24\u2009h of diagnosis. Histopathology revealed perforated appendicitis in two patients. There were no perioperative complications. Oral feeding was resumed within 1\u20136\u2009days (median: 2), and no patients experienced wound infections or surgical delays in further treatment. One patient died due to progression of underlying disease, unrelated to appendicitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the immunosuppressed state and neutropenia, early laparoscopic appendectomy was safe and effective in pediatric HSCT recipients, supporting its use as a first\u2010line treatment strategy in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70287","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:57:24Z","timestamp":1772967444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Appendicitis in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Single\u2010Center Experience"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-5183","authenticated-orcid":false,"given":"Mustafa","family":"Okumu\u015f","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Surgery Yeni Y\u00fczy\u0131l University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-3106","authenticated-orcid":false,"given":"Dilek","family":"Ece","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Hematology and Oncology Yeni Y\u00fczy\u0131l University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-0582","authenticated-orcid":false,"given":"Avni","family":"Atay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Hematology and Bone Marrow Transplantation Unit Yeni Y\u00fczy\u0131l University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-814X","authenticated-orcid":false,"given":"Bar\u0131\u015f","family":"Malbora","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Hematology and Bone Marrow Transplantation Unit Yeni Y\u00fczy\u0131l University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.0885"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115734"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"32","article-title":"Appendicitis","volume":"25","author":"McBurney C.","year":"1895","journal-title":"Southern Medical 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