{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:02:58Z","timestamp":1789653778964,"version":"4.0.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffuse infantile hepatic hemangiomas can lead to complications such as high\u2010output heart failure, hypothyroidism, abdominal compartment syndrome, and hepatic failure. Medical management with propranolol is first\u2010line therapy; however, treatment failure may occur in severe cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We described the case of a 2\u2010month\u2010old male with multiple cutaneous infantile hemangiomas and diffuse hepatic hemangiomas who presented with acute liver failure and cardiorespiratory insufficiency despite optimal treatment with propranolol. The patient was urgently listed for liver transplantation with a Pediatric End\u2010Stage Liver Disease (PELD) score of 23 and weight &lt;\u20095\u2009kg. The infant underwent orthotopic liver transplantation from a deceased donor with caval replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Immunohistochemical staining of the liver and adrenal lesions was diffusely and strongly positive for GLUT1, consistent with infantile hemangioma. Liver function labs normalized immediately post\u2010operatively without perioperative complications or rejection. The patient is growing and developing normally at 10\u2009months after transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights liver transplantation as a definitive treatment for hemangioma\u2010related acute liver failure when propranolol therapy fails. Timely referral for transplantation is critical in optimizing outcomes in this rare but severe condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70294","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:24:50Z","timestamp":1773116690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Liver Transplantation for Diffuse Infantile Hepatic Hemangioma and Acute Liver Failure: A Case Report"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1471-5619","authenticated-orcid":false,"given":"Elana P.","family":"Kleinman","sequence":"first","affiliation":[{"name":"Department of Pediatrics MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-4343","authenticated-orcid":false,"given":"Nada A.","family":"Yazigi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics MedStar Georgetown University Hospital  Washington DC USA"},{"name":"MedStar Georgetown Transplant Institute  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8018-9840","authenticated-orcid":false,"given":"Carolina","family":"Rumbo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics MedStar Georgetown University Hospital  Washington DC USA"},{"name":"MedStar Georgetown Transplant Institute  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6644-8683","authenticated-orcid":false,"given":"Roaa A.","family":"Aljuaid","sequence":"additional","affiliation":[{"name":"Department of Pathology MedStar Georgetown University Hospital  Washington DC 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MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-1572","authenticated-orcid":false,"given":"Anna Yasmine","family":"Kirkorian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children's National Hospital  Washington DC USA"},{"name":"George Washington University, School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-4665","authenticated-orcid":false,"given":"Colleen H.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children's National Hospital  Washington DC USA"},{"name":"George Washington University, School of Medicine and Health Sciences  Washington DC 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