{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:02:57Z","timestamp":1789653777514,"version":"4.0.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human adenovirus in immunocompromised patients can be life\u2010threatening. We describe the prevalence, clinical presentation, and treatment of adenovirus after pediatric liver transplantation at a large transplant center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of adenovirus infection in children from 2013 to 2022. We compared incidence, clinical characteristics, and outcomes of post\u2010transplant children by adenovirus treatment status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adenovirus disease developed in 26% (84\/320) children after liver transplant. Median age at liver transplant was 17.5\u2009months, 48% were female; 50% had biliary atresia. Fever (53%), gastrointestinal symptoms (48%), and hepatitis (41%) were the most common clinical presentations at diagnosis. Median time to adenovirus diagnosis was 80\u2009days (IQR 19\u2013260) with 40% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931\/84) identified within 30\u2009days post\u2010transplant. Disseminated adenovirus (\u2265\u20092 organ involvement) occurred in 24% (20\/84). Fourteen patients (17%) received cidofovir, and most (13\/14, 93%) had DNAemia, compared to 57% untreated patients with DNAemia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). Median peak adenovirus load was 491\u2009805 copies\/mL (IQR 24\u2009800\u20131\u2009900\u2009000) in treated vs. 1000 copies\/mL (IQR 595\u2013794\u2009794) in untreated patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Overall mortality was 8% (7\/84).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of symptomatic and disseminated adenovirus disease was high in our pediatric liver transplant patients, particularly within 30\u2009days post\u2010transplant. Patients who received cidofovir treatment presented with high viral load and had the highest mortality. There is a critical need for evidence\u2010based guidance for early antiviral management of adenovirus disease after pediatric liver transplant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70298","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:20:59Z","timestamp":1773915659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenovirus Disease Following Pediatric Liver Transplantation: 10\u2010Year Experience From a Large Pediatric Transplant Program"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-8870","authenticated-orcid":false,"given":"Anna M.","family":"Banc\u2010Husu","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-9425","authenticated-orcid":false,"given":"Sara","family":"Hassan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of Texas Southwestern, Children's Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1289-4692","authenticated-orcid":false,"given":"N. Thao N.","family":"Galvan","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation, Michael E. De Bakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-1395","authenticated-orcid":false,"given":"Elizabeth A.","family":"Moulton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-9562","authenticated-orcid":false,"given":"Jeremy M.","family":"Schraw","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Hosek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Quality Outcomes and Analytics Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Cerminara","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-7689","authenticated-orcid":false,"given":"Flor M.","family":"Munoz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-5518","authenticated-orcid":false,"given":"Krupa","family":"Mysore","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24677"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.07.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000558"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13496"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80593-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0628-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992280404300303"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584923"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00116-13"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000451"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.12.013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13527"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13510"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v17050599"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181fefa1f"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.01014.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13231"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01443.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200210150-00027"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.1.170"},{"issue":"5","key":"e_1_2_8_23_1","first-page":"599","article-title":"Human Herpesvirus 6 Infection in Pediatric Liver Transplantation: Single\u2010Center Study of Incidence, Outcomes, and Management","volume":"10","author":"Mysore K. 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