{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:02:56Z","timestamp":1789653776874,"version":"4.0.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urothelial bladder carcinoma is extremely rare in children and its association with BK virus infection remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We describe the case of an 11\u2010year\u2010old girl who developed a urothelial carcinoma of the bladder four years after receiving her first kidney transplant. Kidney failure was secondary to nephronophthisis (\n                      <jats:italic>NPHP6<\/jats:italic>\n                      variant), diagnosed in the neonatal period and associated with Leber congenital amaurosis and intellectual disability. She underwent peritoneal dialysis for four years before kidney transplantation at 6.5\u2009years of age. Five months post\u2010transplant, she developed BK virus\u2010associated nephropathy, leading to chronic allograft dysfunction. Four years later, a routine ultrasound revealed an asymptomatic bladder mass without evidence of extension. The lesion was resected endoscopically and later managed with partial cystectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histopathologic analysis confirmed a high\u2010grade invasive urothelial carcinoma (pT2). Immunohistochemistry showed SV40 positivity, consistent with BK virus\u2010induced neoplasia, while non\u2010tumoral cells were negative. BK viremia had been undetectable one year prior to diagnosis. The patient remained disease\u2010free for seven years following surgery, without adjuvant therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The involvement of BK virus in the development of bladder cancer has not yet been clarified. This case supports a possible role of BK virus in urothelial tumorigenesis, particularly in immunosuppressed transplant recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70303","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:05:53Z","timestamp":1773972353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urothelial Carcinoma of the Bladder Following\n                    <scp>BK<\/scp>\n                    Virus Infection in a Pediatric Kidney Transplant Recipient"],"prefix":"10.1111","volume":"30","author":[{"given":"Martina","family":"Ichas","sequence":"first","affiliation":[{"name":"Service de N\u00e9phrologie P\u00e9diatrique, CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Allard","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie P\u00e9diatrique, CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Harper","sequence":"additional","affiliation":[{"name":"Service de Chirurgie P\u00e9diatrique, CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mokrane","family":"Yacoub","sequence":"additional","affiliation":[{"name":"Service de Pathologie, CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona","family":"Madden","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie P\u00e9diatrique, CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"V\u00e9rit\u00e9","sequence":"additional","affiliation":[{"name":"Service D'h\u00e9mato\u2010Oncologie P\u00e9diatrique, CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Godron\u2010Dubrasquet","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie P\u00e9diatrique, CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Harambat","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie P\u00e9diatrique, CHU de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2019.06.013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2018.03.002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.033"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.t01-1-00037.x"},{"issue":"4","key":"e_1_2_5_6_1","first-page":"514","article-title":"Polyomavirus Nephropathy","volume":"16","author":"Ramos E.","year":"2005","journal-title":"Saudi Journal of Kidney Diseases and Transplantation"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1407-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00855.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12752"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531822"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","unstructured":"D.Geetha B. C.Tong L.Racusen J. S.Markowitz andW. H.Westra \u201cBladder Carcinoma in a Transplant Recipient: Evidence to Implicate the BK Human Polyomavirus as a Causal Transforming Agent: Transplantation \u201d73 no.12(2002) 1933\u20131936.","DOI":"10.1097\/00007890-200206270-00015"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.09.019"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx123.264"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.09.037"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04248.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.08.138"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.02.068"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20429"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14530"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2019.06.009"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13550"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.70303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:11:54Z","timestamp":1789650714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/petr.70303"],"URL":"https:\/\/doi.org\/10.1111\/petr.70303","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70303"}}