{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:34:13Z","timestamp":1777948453111,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023194","name":"Canadian Donation and Transplantation Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012395","name":"Canadian Immunization Research Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012285","name":"BC Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Children with solid organ transplants (SOT) face higher risks of severe disease from varicella\u2010zoster virus (VZV). Although some guidelines recommend live attenuated varicella vaccine (LAVV) for select children post SOT, further real\u2010world vaccine immunogenicity and safety data are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective observational study was conducted at 4 Canadian centres from 2020 to 2023. Children who were 1\u201319\u2009years, VZV IgG negative, &gt;\u20091\u2009year post liver, kidney, or heart transplant, and were receiving LAVV as part of clinical care in accordance with centre\u2010specific criteria were eligible for inclusion. Measurement of VZV IgG was recommended post\u2010vaccination with LAVV. Adverse events following immunization (AEFIs) were captured via telephone survey and chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010six pediatric SOT recipients (51 liver, 3 kidney, and 2 heart) received \u2265\u20091 dose of LAVV. Serology after the last post\u2010transplant dose of LAVV was available for 43\/56 (77%) participants; 39\/43 (91%) seroconverted to positive VZV IgG (12\/16 after 1 post\u2010transplant dose, 26\/30 after 2 doses and 1\/1 after 3 doses). Among 56 dose 1 recipients, 6 (11%) experienced an AEFI requiring medical attention. Four had rash: 3 with varicella\u2010like rash (1\/3 confirmed vaccine\u2010strain varicella) and none required antivirals. Two had acute rejection 4\u20135\u2009weeks after LAVV. Two of 38 (5%) dose 2 recipients had an AEFI requiring medical attention, with one serious AEFI 7\u2009weeks after LAVV that was not deemed vaccine\u2010related after careful review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      LAVV was immunogenic and generally well tolerated in our cohort of patients. Post\u2010SOT LAVV should be considered for select VZV seronegative children with close follow\u2010up\n                      <jats:italic>.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70314","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:18:56Z","timestamp":1775449136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunogenicity and Safety of Live Attenuated Varicella Vaccine in Children and Youth With Solid Organ Transplants in Canada: A Canadian Immunization Research Network Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-5582","authenticated-orcid":false,"given":"Catherine","family":"Burton","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Stollery Children's Hospital University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo Lin","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Sadarangani","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, BC Children's Hospital Research Institute  Vancouver Canada"},{"name":"Department of Pediatrics, Faculty of Medicine University of British Columbia Centre  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-0197","authenticated-orcid":false,"given":"Tom","family":"Blydt\u2010Hansen","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, BC Children's Hospital Research Institute  Vancouver Canada"},{"name":"Department of Pediatrics, Faculty of Medicine University of British Columbia Centre  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soren","family":"Gantt","sequence":"additional","affiliation":[{"name":"Centre de Recherche Azrieli du Centre Hospitalier Universitaire de Ste\u2010Justine et D\u00e9partement de Microbiologie, Infectiologie et Immunologie Universit\u00e9 de Montr\u00e9al  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun K.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Child Health Evaluative Sciences, Hospital for Sick Children and Department of Pediatrics University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-1860","authenticated-orcid":false,"given":"Sneha","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Stollery Children's Hospital University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Pham\u2010Huy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Eastern Ontario University of Ottawa  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Otley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IWK Health Centre Dalhousie University  Halifax Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Tapiero","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Ste\u2010Justine Universit\u00e9 of Montr\u00e9al  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, BC Children's Hospital Research Institute  Vancouver Canada"},{"name":"Department of Pediatrics, Faculty of Medicine University of British Columbia Centre  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-5109","authenticated-orcid":false,"given":"Juthaporn","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ottawa at the Ottawa Hospital  Ottawa Canada"},{"name":"Inflammation and Chronic Disease Program The Ottawa Hospital Research Institute  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Sivro","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory Branch, Public Health Agency of Canada  Winnipeg Manitoba Canada"},{"name":"Department of Medical Microbiology and Infectious Diseases, Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba 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