{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:34:08Z","timestamp":1777948448629,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","award":["IG2013\u2010JP"],"award-info":[{"award-number":["IG2013\u2010JP"]}],"id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The risk factors for donor\u2010acquired (DA) CMV transmission in CMV\u2010seronegative pediatric solid organ transplant (SOT) recipients (R\u2010) receiving organs from CMV\u2010seropositive donors (D+) remain unknown in the era of routine antiviral prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DA\u2010CMV transmission was defined as CMV antigenemia\/DNAemia and\/or seroconversion in a D+\/R\u2010 recipient by 13\u2009months post\u2010transplant. DA\u2010CMV transmission, along with donor and recipient demographics, was studied in a retrospective cohort of CMV D+\/R\u2010 children who had a SOT at the Stollery Children's Hospital from 2000 to 2018. All patients were expected to receive at least 3\u2009months of CMV\u2010active antiviral prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      105 CMV D+\/R\u2010 pediatric SOT recipients (48 liver, 35 heart, 4 lung, 18 kidney) were analyzed; DA\u2010CMV transmission occurred in 58 patients (55%). Frequency of DA\u2010CMV transmission was highest in lung (75%), followed by liver (69%), then kidney (61%), and was lowest in heart recipients (31%). Median time to DA\u2010CMV transmission was 4.8\u2009months (3.4\u20136.7). In a multivariable cox regression model including organ, donor and recipient age and sex, risk of DA\u2010CMV transmission was significantly lower in heart versus liver recipients (HR 0.30, 95% CI 0.14, 0.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Understanding factors that result in non\u2010transmission of CMV to seronegative recipients despite receiving a seropositive organ may guide more targeted use of antiviral prophylaxis in pediatric SOT recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70316","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:30:09Z","timestamp":1775795409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transmission of Cytomegalovirus (\n                    <scp>CMV<\/scp>\n                    ) from CMV\u2010Seropositive Organ Donors to CMV\u2010Seronegative Pediatric Solid Organ Transplant (\n                    <scp>SOT<\/scp>\n                    ) Recipients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-2871","authenticated-orcid":false,"given":"Geraldine","family":"Huynh","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta 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Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-5582","authenticated-orcid":false,"given":"Catherine","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta 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