{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:56:13Z","timestamp":1781279773295,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The gold\u2010standard for the diagnosis and management of biliary complications, particularly biliary strictures in pediatric liver transplant (LT) recipients is percutaneous transhepatic cholangiogram (PTC) followed by biliary drainage (PTBD). Despite the established role of PTBD in managing biliary complications in pediatric LT recipients, limited data exist on post\u2010procedural infection rates and optimal antibiotic prophylaxis strategies. The primary aim was to analyze the complications of PTBD in pediatric LT recipients. The secondary aim was to analyze factors associated with PTBD complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the medical records of children having undergone LT between August 2004 and October 2020 in our center. Patients who developed a biliary complication treated by PTBD were selected. We then compared PTBD patients with complications to those without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven patients underwent 35 percutaneous transhepatic biliary drainage (PTBD) sessions. Biliary atresia was the most frequent indication for LT in 6\/11 (54%) children. Ten (10\/11; 91%) received a left lateral segment, and all had undergone biliary\u2010enteric anastomosis. Anastomotic stricture was the most common finding on PTC in 22\/35 (63%) sessions. 25\/35 (71%) PTBD were conducted using one\u2010day antibiotic prophylaxis and 10\/35 (29%) using extended\u201024\u2010h antibiotherapy. Of 35 PTBD sessions, 17\/35 (49%) experienced complications, primarily infectious (40%; 14\/35). We compared different antibioprophylaxis regimens in 14 PTBD with infection. There was a trend to a lower incidence of infections in the extended\u201024\u2010h antibiotherapy group (10%; 1\/10) compared to the one\u2010day antibiotic prophylaxis group (52%; 13\/25) with a relative risk of 0.19 (0.03\u20131.28).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PTBD is associated with a high rate of post\u2010procedure infectious complications. These complications result in a high burden and morbidity. There was a trend to an association between extended\u201024\u2010h antibiotherapy and the absence of infectious complications after PTBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70328","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:10:16Z","timestamp":1777983016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infectious Complications After Percutaneous Transhepatic Biliary Drainage in Pediatric Liver Transplant Recipients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5539-9870","authenticated-orcid":false,"given":"Isaline","family":"Chabbey","sequence":"first","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University of Geneva  Geneva Switzerland"},{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Unit, Division of Pediatric Subspecialities, Department of Pediatrics, Gynecology, and Obstetrics  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Barooty","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Mucosal Immunology Unit Great Ormond Street Hospital (GOSH)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Calinescu","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University of Geneva  Geneva Switzerland"},{"name":"Division of Child and Adolescent Surgery, Department of Pediatrics, Gynecology, and Obstetrics University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Silvestrini","sequence":"additional","affiliation":[{"name":"Clinical Research Center University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9230-7285","authenticated-orcid":false,"given":"Arnaud G.","family":"L'Huillier","sequence":"additional","affiliation":[{"name":"Paediatric Infectious Diseases Unit, Department of Pediatrics, Gynecology and Obstetrics University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-382X","authenticated-orcid":false,"given":"Barbara E.","family":"Wildhaber","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University of Geneva  Geneva Switzerland"},{"name":"Division of Child and Adolescent Surgery, Department of Pediatrics, Gynecology, and Obstetrics University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Terraz","sequence":"additional","affiliation":[{"name":"Radiology Department and Center for Hepatobiliary and Pancreatic Disorder  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"McLin","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University of Geneva  Geneva Switzerland"},{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Unit, Division of Pediatric Subspecialities, Department of Pediatrics, Gynecology, and Obstetrics  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Rock","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University of Geneva  Geneva Switzerland"},{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition Unit, Division of Pediatric Subspecialities, Department of Pediatrics, Gynecology, and Obstetrics  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10030282"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.3.1760761"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i18.2162"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010024\u201006735\u20106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010021\u201005212\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12363"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.12.034"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2007.01893.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477\u20102574.2011.00300.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/mot.0000000000000083"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010018\u201004076\u2010x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.07.023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14727"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.26379"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010021\u201005278\u20103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010010\u20101217\u20102"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.09.3925"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.03.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2025.28.2.113"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13995"}],"container-title":["Pediatric 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