{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:57:37Z","timestamp":1781279857066,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>POLD1 defect with immunodeficiency is characterized by T\u2010cell and NK\u2010cell lymphopenia, with the patients having a higher susceptibility to herpetic and viral respiratory tract infections. Patients considered for HSCT may be at increased risk of regimen\u2010related toxicity due to impaired DNA repair. Here, we describe the first case of successful HSCT in a patient with POLD1 deficiency who presented at a relatively older age for immunodeficiency and underwent HSCT despite concerns about DNA\u2010related toxicity from the conditioning regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report the first successful HSCT in an 18\u2010year\u2010old woman with POLD1 deficiency who had recurrent pulmonary infections and shingles, and who was IgRT\u2010dependent. The decision was made to perform HSCT from her matched related donor after informing the family that there was a concern about DNA\u2010related toxicity following the HSCT procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>She underwent HSCT from a matched related donor using a reduced\u2010intensity regimen (cyclophosphamide, fludarabine, ATG) with bone marrow and peripheral blood as stem cell sources. GVHD prophylaxis included tacrolimus and low\u2010dose methotrexate. Engraftment occurred promptly, without major complications. Post\u2010HSCT follow\u2010up demonstrated improved T\u2010cell counts and function, and the patient remained well without IgRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This first report of HSCT in POLD1 deficiency shows that reduced\u2010intensity conditioning can achieve engraftment with minimal toxicity, supporting HSCT as a feasible option for these patients. The success of HSCT will be understood more clearly as the cases are presented.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70331","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:53:36Z","timestamp":1778302416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Treatment of\n                    <scp>POLD1<\/scp>\n                    Deficiency With\n                    <scp>HSCT<\/scp>\n                    : Report of Two Years' Experience"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-8947","authenticated-orcid":false,"given":"Sevgi","family":"Keles","sequence":"first","affiliation":[{"name":"Necmettin Erbakan University, Medical Faculty, Division of Pediatric Allergy and Immunology  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3257-7798","authenticated-orcid":false,"given":"Vedat","family":"Uygun","sequence":"additional","affiliation":[{"name":"\u0130stinye University, Faculty of Medicine, MedicalPark Antalya Hospital, Department of Pediatric Bone Marrow Transplantation Unit  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-8945","authenticated-orcid":false,"given":"Mehmet Ali","family":"Karaselek","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Medical Faculty, Division of Pediatric Allergy and Immunology  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8445-666X","authenticated-orcid":false,"given":"Serkan","family":"K\u00fc\u00e7\u00e7\u00fckt\u00fcrk","sequence":"additional","affiliation":[{"name":"Karamano\u011flu Mehmetbey University, Medicine Faculty, Division of Medical Biology  Karaman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5848-7179","authenticated-orcid":false,"given":"Oznur","family":"Dogar","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Medical Faculty, Division of Pediatric Allergy and Immunology  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-2876","authenticated-orcid":false,"given":"Gunhal","family":"Sat\u0131rtav","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Medical Faculty, Division of Ophthalmalogy  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-8486","authenticated-orcid":false,"given":"Seyma Celikbilek","family":"Celik","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Medical Faculty, Division of Pediatric Allergy and Immunology  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-2132","authenticated-orcid":false,"given":"Bahad\u0131r","family":"Feyzioglu","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Medical Faculty, Division of Microbiology  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8860-6132","authenticated-orcid":false,"given":"Sukru","family":"Guner","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Medical Faculty, Division of Pediatric Allergy and Immunology  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8247-6405","authenticated-orcid":false,"given":"Ismail","family":"Reisli","sequence":"additional","affiliation":[{"name":"Necmettin Erbakan University, Medical Faculty, Division of Pediatric Allergy and Immunology  Konya 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