{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:57:09Z","timestamp":1781279829349,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015217","name":"Veloxis Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM008562"],"award-info":[{"award-number":["T32GM008562"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complicated immunosuppression regimens can contribute to non\u2010adherence in pediatric solid organ transplant (SOT) recipients. Once\u2010daily tacrolimus formulations, such as LCP\u2010tacrolimus (LCPT), may help simplify dosing, but pediatric data on dosing, safety, and early tolerability are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single center retrospective cohort study of SOT recipients prescribed LCPT from December 2016 to July 2024 at our institution. LCPT:IR\u2010Tac daily dosing ratios were calculated. The frequency of laboratory\u2010associated adverse events (AE) and of new patient\u2010reported adverse events in the first 90\u2009days were collected and compared across pediatric\u2010 and adult\u2010aged SOT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety\u2010one SOT recipients were prescribed LCPT at a median age of 16.8\u2009years (range 8.4\u201324.1) and 75\u2009months after transplant (range 0.25\u2013217). Among 53 patients who were therapeutic on both IR\u2010Tac and LCPT, the median daily dosing ratio of LCPT:IR\u2010Tac was 0.75 (range 0.33\u20131.5) for pediatric patients and 0.75 (IQR: 0.46\u20131.33) for adults. Eleven (5 patient\u2010reported and 6 laboratory) AEs were identified, none of which resulted in cessation of LCPT therapy. There were no significant differences in the frequency of AEs between children and adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LCPT was well tolerated and typically required about a 25% dose reduction compared with IR\u2010tacrolimus, though conversion ratios varied widely. These findings offer practical guidance for LCPT dosing in pediatric transplant care and highlight the need for individualized titration and monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70349","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T11:23:46Z","timestamp":1779535426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosing, Safety, and Tolerability of Extended\u2010Release Tacrolimus in Pediatric and Young Adult Solid Organ Transplant Recipients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-8039","authenticated-orcid":false,"given":"Terry","family":"Dang","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Postdoctoral Training Program Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8418-0741","authenticated-orcid":false,"given":"Jennifer","family":"Hewlett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8913-6219","authenticated-orcid":false,"given":"John","family":"McAteer","sequence":"additional","affiliation":[{"name":"Division of Nephrology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Division of Infectious Diseases Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-8146","authenticated-orcid":false,"given":"Kevin J.","family":"Downes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.01.023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1310\/hpj5202-124"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180829101836"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15909"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-018-3892-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000517"},{"key":"e_1_2_9_8_1","volume-title":"Product Label: Envarus XR (Tacrolimus Extended\u2010Release 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