{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:56:08Z","timestamp":1789541768782,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric kidney transplant recipients typically receive low\u2010KDPI deceased donor kidneys but often experience higher HLA mismatches. The relationship between KDPI and HLA mismatch and their combined effect on graft and patient outcomes in children has not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of SRTR data in evaluating the association between KDPI and HLA mismatch. We included all pediatric kidney transplant recipients under 21\u2009years of age who received a transplant between December 4, 2014, to December 31, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant difference in death\u2010censored graft survival between KDPI &lt;\u200930% and\u2009\u2265\u200930% (HR 0.74; 95% CI: 0.51\u20131.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.11). However, recipients with HLA MM of 3\u20136 had significantly worse graft survival than those with 0\u20132 mismatches (HR 0.62; 95% CI: 0.42\u20130.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). In combined models, any group with HLA MM 3\u20136 had worse graft survival regardless of KDPI. No significant differences were found in patient survival across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HLA mismatch is a stronger predictor of graft outcomes than KDPI in pediatric kidney transplantation. The limited number of high\u2010KDPI donors in pediatric recipients may explain the lack of significant association with KDPI. These findings support efforts to minimize HLA mismatches in pediatric allocation strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70351","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:08:42Z","timestamp":1781082522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Kidney Donor Profile Index and Human Leukocyte Antigen Mismatch on Graft Survival in Pediatric Kidney Transplant Recipients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-4239","authenticated-orcid":false,"given":"Saritha","family":"Ranabothu","sequence":"first","affiliation":[{"name":"Pediatric Nephrology Arkansas Children's Hospital, University of Arkansas Medical Sci Ences  Little Rock USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-4267","authenticated-orcid":false,"given":"Jodi M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Seattle Children's Hospital  Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6935-0012","authenticated-orcid":false,"given":"James","family":"Perkins","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery University of Washington  Seattle USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-8132","authenticated-orcid":false,"given":"Lyndsay","family":"Harshman","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology University of Iowa Organ Transplant Center  Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-9751","authenticated-orcid":false,"given":"Sharon M.","family":"Bartosh","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology University of Wisconsin School of Medicine and Public Health  Madison USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-7951","authenticated-orcid":false,"given":"Rachel M.","family":"Engen","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology University of Wisconsin School of Medicine and Public Health  Madison 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