{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:07:00Z","timestamp":1788858420492,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cryptogenic liver cirrhosis in infancy is rare, and its coexistence with hepatoblastoma (HB) has not been previously documented. While HB generally arises in morphologically normal livers, the incidental discovery of HB within cirrhotic livers is exceptional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report a 6\u2010month\u2010old male infant with progressive cholestasis. Prenatal assessments indicated growth restriction and blood flow redistribution, and he was delivered preterm at 33\u2009weeks and 6\u2009days with a birth weight of 861\u2009g (\u22124.1 SD). Despite extensive clinical, metabolic, infectious, and genetic evaluations, no etiology of cholestasis was identified. Liver function was deteriorated with a Child\u2010Pugh score of 8 (Grade B) and a Pediatric End\u2010Stage Liver Disease Score of 20. The patient underwent living donor liver transplantation at 6\u2009months of age (body weight: 4.446\u2009kg). Histopathological examination of the explanted liver revealed advanced fibrosis, and unexpectedly, a microscopic hepatoblastoma (approximately 1\u2009mm, fetal type) was detected. The high level of serum AFP rapidly normalized postoperatively, and the infant was discharged in good condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case highlights a unique presentation of infantile cryptogenic cirrhosis with incidental HB. Although HB typically develops in non\u2010cirrhotic livers, hepatic injury and regenerative processes may create a permissive environment for tumorigenesis of HB in cirrhotic liver. The incidental finding of one millimeter HB emphasizes the importance of thorough histopathological evaluation of explanted livers. Moreover, careful postoperative surveillance with AFP monitoring and imaging remains essential to detect recurrence, as localized HB after complete resection carries a reported recurrence risk of approximately 6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first reported case of incidental HB arising in infantile cryptogenic cirrhosis. It expands the clinical spectrum of HB in infantile cryptogenic cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70369","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T13:05:55Z","timestamp":1781096755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidental Hepatoblastoma in an Infant Who Underwent Liver Transplantation for Cryptogenic Liver Cirrhosis: A Case Report"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-0289","authenticated-orcid":false,"given":"Masato","family":"Kojima","sequence":"first","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Hattori","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2441-5158","authenticated-orcid":false,"given":"Hajime","family":"Uchida","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-4790","authenticated-orcid":false,"given":"Ryuji","family":"Komine","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-5548","authenticated-orcid":false,"given":"Yusuke","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4684-0446","authenticated-orcid":false,"given":"Akinari","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuko","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Pathology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Pathology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-7319","authenticated-orcid":false,"given":"Seisuke","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Organ 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