{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:40:07Z","timestamp":1790026807241,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescence has been identified as a high\u2010risk period for graft failure. However, existing knowledge on this topic is largely limited to long\u2010term graft outcomes. The aim of this study was to examine the association between age at kidney transplantation and early graft loss, defined as graft failure within 3\u2009years post\u2010transplantation in the contemporary era.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a retrospective analysis of 55\u2009973 first\u2010time kidney transplant recipients identified in the U.S. Renal Data System from January 1, 2005, to December 31, 2021. Adjusted Cox proportional hazards regression models were used to evaluate the association between age at transplantation and early graft failure including an interaction term for race\/ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adolescents (12 to &lt;\u200918\u2009years) and young adults (18 to &lt;\u200926\u2009years) were at the highest risk of early death\u2010censored graft loss compared to young adults (26 to &lt;\u200940\u2009years), with hazard ratios of 1.95 (95% CI 1.74\u20132.17) and 2.01 (95% CI 1.86\u20132.17), respectively. Additionally, we found that the effect of age on early graft loss varied significantly by race, with disparities observed among Asian and Black youth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight a persistently elevated risk in adolescents and young adults in the contemporary era.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70373","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:50:26Z","timestamp":1780901426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Age at Kidney Transplantation and Risk of Early Graft Loss"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4988-1257","authenticated-orcid":false,"given":"Karina Alas","family":"Marroquin","sequence":"first","affiliation":[{"name":"UCLA Department of Internal Medicine University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle","family":"Frazier","sequence":"additional","affiliation":[{"name":"UCSF Benioff Children's Physicians Pediatric Hematologist University of California, San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-6179","authenticated-orcid":false,"given":"Charles E.","family":"McCulloch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-2526","authenticated-orcid":false,"given":"Elaine","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California, San Francisco  San Francisco California USA"},{"name":"Division of Nephrology, Department of Pediatrics University of California, San Francisco  San Francisco California USA"},{"name":"Division of Nephrology, Department of Medicine University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.197"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2018.09.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103046.2007.00886.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010014\u20102859\u20107"},{"key":"e_1_2_8_6_1","volume-title":"Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data January 1, 1988\u2013February 28, 2025","author":"Ann Arbor 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