{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:07:00Z","timestamp":1788858420504,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015217","name":"Veloxis Pharmaceuticals","doi-asserted-by":"publisher","award":["GRN\u201015030"],"award-info":[{"award-number":["GRN\u201015030"]}],"id":[{"id":"10.13039\/100015217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescents receiving solid organ transplants (SOT) are at increased risk for rejection and graft loss, driven by suboptimal immunosuppressive medication adherence. This study evaluated the effect of conversion from immediate\u2010release tacrolimus (IR\u2010Tac) to extended\u2010release tacrolimus (LCPT) on medication adherence in pediatric SOT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, observational single\u2010center study of heart, liver, and kidney transplant recipients who converted from IR\u2010Tac to LCPT. Medication adherence was measured as tacrolimus standard deviation (tac\u2010SD), with tac\u2010SD &gt;\u20092 considered the threshold for poor adherence, and self\u2010reported adherence during the one year before and after conversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four pediatric SOT recipients were included, with a median age of 9\u2009years at transplant and 14.4\u2009years at conversion from IR\u2010Tac to LCPT. Among the entire cohort, overall tac\u2010SD did not differ before and after conversion. Among children with high baseline variability (tac\u2010SD &gt;\u20092), tac\u2010SD significantly decreased from a median of 3.0 to 2.7 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), whereas children with low baseline variability (tac\u2010SD &lt;\u20092) experienced a significant increase in tac\u2010SD from 1.3 to 2.2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The proportion of children reporting missed doses more than once a week decreased from 13 (24%) to 7 (13%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07). There was no change in tac\u2010SD between children who were and were not converted to LCPT for an adherence concern.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tac\u2010SD decreased after conversion from IR\u2010Tac to LCPT among those with high baseline variability but increased among those with low baseline variability; there were no significant changes in subjective adherence measures. The effectiveness of conversion from IR\u2010Tac to LCPT for adherence is unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70381","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:57:01Z","timestamp":1782208621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tacrolimus variability and medication adherence pre\u2010 and post\u2010conversion from immediate\u2010release to extended\u2010release tacrolimus in pediatric solid organ transplant"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-2065","authenticated-orcid":false,"given":"Leandra","family":"Bitterfeld","sequence":"first","affiliation":[{"name":"Intermountain Primary Children's Hospital  Salt Lake City Utah USA"},{"name":"School of Medicine Stanford University  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-3340","authenticated-orcid":false,"given":"Rachel L.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Intermountain Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-9263","authenticated-orcid":false,"given":"Jorge","family":"Sanchez\u2010Garcia","sequence":"additional","affiliation":[{"name":"Intermountain Health  Salt Lake City Utah USA"},{"name":"Department of Surgery Florida Atlantic University  Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9085-0657","authenticated-orcid":false,"given":"Bridget","family":"Bucher","sequence":"additional","affiliation":[{"name":"University of Utah Health  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6796-028X","authenticated-orcid":false,"given":"Ashlie","family":"Brewer","sequence":"additional","affiliation":[{"name":"Intermountain Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5803-8226","authenticated-orcid":false,"given":"Caroline","family":"Heyrend","sequence":"additional","affiliation":[{"name":"Intermountain Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32834a8c89"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103046.2005.00451.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31823411d7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13717"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.07.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253\u20107613.174425"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020272"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S54922"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010024\u201006497\u20100"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.06.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13709"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12648"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.6002\/ect.pedsymp2024.O17"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13346"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/2020.coling\u2010main.60"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2013.0060"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13616"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103046.2010.01396.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.05.028"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.01.023"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13142\u2010015\u20100315\u20102"},{"key":"e_1_2_10_23_1","volume-title":"StatPearls","author":"Araya A. 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