{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:58:48Z","timestamp":1790413128483,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric lung transplantation remains a life\u2010saving option for selected children and adolescents with end\u2010stage lung disease. We aimed to describe clinical characteristics, survival, post\u2010transplant morbidity, and exploratory factors associated with mortality in a single\u2010center Saudi cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed all pediatric patients who underwent lung transplantation between January 2010 and December 2023. Demographic, anthropometric, perioperative, and post\u2010transplant data were extracted. Survival was assessed with Kaplan\u2013Meier analysis, and Cox regression was used to explore associations with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight recipients underwent transplantation, predominantly bilateral sequential procedures, at a median age of 16\u2009years. All recipients were adolescents, and cystic fibrosis (CF) was the most common indication. Severe undernutrition was common, with 64.3% meeting failure\u2010to\u2010thrive criteria (&lt;\u20091st centile for weight) and 71.4% below the 3rd centile. Intraoperative extracorporeal membrane oxygenation replaced cardiopulmonary bypass after 2016. One\u2010year survival was 96.4%, and median post\u2010transplant survival was 6.8\u2009years. Survival did not differ significantly by intraoperative extracorporeal support, but median survival was shorter in CF than in non\u2010CF recipients (2.9 vs. 8.9\u2009years). Hypertension developed in 53.5% of patients, diabetes in 28.5%, and acute kidney injury in 46.4%. In age\u2010 and sex\u2010adjusted Cox models, CF, longer waiting time,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      <\/jats:styled-content>\n                      colonization, and diabetes at 1\u2009year were associated with mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pediatric lung transplantation in this cohort achieved excellent short\u2010term survival but substantial long\u2010term morbidity. Mortality associations should be interpreted cautiously, given the small sample size and event count. The shorter survival observed in CF recipients warrants further study, particularly in the context of severe undernutrition and chronic airway colonization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70392","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:43:24Z","timestamp":1783154604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010Center Experience in Pediatric Lung Transplantation: Clinical Characteristics, Survival, and Post\u2010Transplant Morbidity"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-7655","authenticated-orcid":false,"given":"Mohammed","family":"Albalawi","sequence":"first","affiliation":[{"name":"Lung Health Center, Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"},{"name":"College of Medicine Alfaisal University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayid","family":"Abdulqawi","sequence":"additional","affiliation":[{"name":"Lung Health Center, Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"},{"name":"College of Medicine Alfaisal University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4211-4896","authenticated-orcid":false,"given":"Abdullah","family":"Alkhani","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital and Research Center, Academic and Training Affairs  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Saleh","sequence":"additional","affiliation":[{"name":"Lung Health Center, Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"},{"name":"College of Medicine Alfaisal University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Hashem","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Transplant Department Royal Papworth Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14126"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.07.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01402-2022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2023.04.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0425OC"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00064804"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1238914"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2019.12.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2015.05.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.36502\/2020\/asjpch.6156"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2020.15"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.05.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.04.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2020.1841630"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-021-01175-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12240"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12339"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2023.12.013"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2013.09.006"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.70392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:21:52Z","timestamp":1790410912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/petr.70392"],"URL":"https:\/\/doi.org\/10.1111\/petr.70392","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70392"}}