{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:34:08Z","timestamp":1792956848546,"version":"4.5.0"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hereditary angioedema (HAE) is a rare autosomal dominant disorder resulting from\n                      <jats:italic>SERPING1<\/jats:italic>\n                      \u2010related C1\u2010inhibitor deficiency. Surgical stress and airway manipulation may precipitate life\u2010threatening attacks. Experience with kidney transplantation in patients with HAE remains extremely limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>We describe a 19\u2010year\u2010old male with end\u2010stage kidney disease secondary to congenital obstructive uropathy and nephrolithiasis, who underwent successful living\u2010donor kidney transplantation from his mother, also diagnosed with HAE type I. Because danazol is unavailable in Argentina, both donor and recipient received compounded stanozolol 2\u2009mg daily, starting 5\u2009days preoperatively and continuing for 5\u2009days postoperatively. Fresh frozen plasma (FFP, 10\u2009mL\/kg) was administered before extubation to raise C1\u2010inhibitor levels, and icatibant was kept on standby for rescue. Neither donor nor recipient experienced perioperative angioedema. Both had uneventful recoveries, with the recipient maintaining stable graft function over 10\u2009months of follow\u2010up (latest serum creatinine 1.4\u2009mg\/dL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This report demonstrates that living\u2010donor kidney transplantation between two individuals affected by HAE can be performed safely with individualized prophylaxis and multidisciplinary coordination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70398","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:03:00Z","timestamp":1783425780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Living\u2010Donor Kidney Transplantation Between Mother and Son With Clinically Confirmed Hereditary Angioedema"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9452-456X","authenticated-orcid":false,"given":"E. M.","family":"Varela","sequence":"first","affiliation":[{"name":"Pediatric Kidney Transplant Instituto de Trasplante y Alta Complejidad \u2010 ITAC  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-0783","authenticated-orcid":false,"given":"D. O.","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Allergy Service Cl\u00ednica Privada Monte Grande  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1891-6765","authenticated-orcid":false,"given":"G.","family":"Filler","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. V.","family":"Rodr\u00edguez Rilo","sequence":"additional","affiliation":[{"name":"Pediatric Kidney Transplant Instituto de Trasplante y Alta Complejidad \u2010 ITAC  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"241","article-title":"Diagnosis and Treatment of Hereditary Angioedema","volume":"54","author":"Canonica G. W.","year":"2012","journal-title":"Panminerva Medica"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23917"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"50","article-title":"Perioperative Management for Patients With Hereditary Angioedema","volume":"6","author":"Williams A. H.","year":"2015","journal-title":"Allergy and Rhinology (Providence)"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-6-24"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14062"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15214"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(87)80277-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.06.037"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R423"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.70398","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:04:02Z","timestamp":1792955042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/petr.70398"],"URL":"https:\/\/doi.org\/10.1111\/petr.70398","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70398"}}