{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:34:21Z","timestamp":1792956861618,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type of venous drainage in isolated intestinal transplantation (ITx) may influence immune responses through hepatic filtration of gut\u2010derived antigens and affect outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed United Network for Organ Sharing data from 2013\u20132023 to compare portal versus systemic drainage in pediatric and adult ITx recipients. Graft and patient survival were assessed using Kaplan\u2013Meier and Cox proportional hazards models, and acute rejection during the index admission was evaluated with multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 480 recipients (137 pediatric, 343 adult), systemic drainage in pediatric patients was associated with higher acute rejection rates (50.7% vs. 32.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029), and adjusted analysis confirmed systemic drainage as an independent risk factor (OR 2.32, 95% CI 1.00\u20135.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049). No survival differences were observed between drainage types in either age group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While venous drainage type did not affect long\u2010term graft or patient survival, portal drainage in pediatric ITx was associated with lower odds of early acute rejection, suggesting a potential immunologic benefit that warrants prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70400","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:40:52Z","timestamp":1785336052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Venous Drainage Route Matter? Portal Versus Systemic Drainage in Isolated Intestinal Transplantation: An Analysis of the National\n                    <scp>UNOS<\/scp>\n                    Database"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8921-0170","authenticated-orcid":false,"given":"Vighnesh","family":"Venkatasamy","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-500X","authenticated-orcid":false,"given":"Amay","family":"Banker","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7236-6966","authenticated-orcid":false,"given":"Mahmoud","family":"Morsi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4675-7095","authenticated-orcid":false,"given":"Gennaro","family":"Selvaggi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2571-9826","authenticated-orcid":false,"given":"Akin","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4543-346X","authenticated-orcid":false,"given":"Rafael","family":"Miyashiro","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-8103","authenticated-orcid":false,"given":"Ahmad","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7557-3063","authenticated-orcid":false,"given":"Jennifer","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-7439","authenticated-orcid":false,"given":"Rodrigo","family":"Vianna","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplant Surgery University of Miami\/Jackson Health System  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2012.04332.x"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"579","article-title":"Portal Versus Systemic Venous Drainage for Small\u2010Bowel Allografts","volume":"98","author":"Schraut W. H.","year":"1985","journal-title":"Surgery"},{"issue":"47","key":"e_1_2_10_4_1","first-page":"1092","article-title":"Kupffer Cell Blockade Inhibits Induction of Tolerance by the Portal Venous Route\u2010PubMed","volume":"6","author":"Callery M. P.","year":"1989","journal-title":"Transplantation"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2023.1179077"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010200104150\u201000004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010200105270\u201000010"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"518","article-title":"Immunologic and Metabolic Effects of Caval Versus Portal Venous Drainage in Small\u2010Bowel Transplantation","volume":"104","author":"Shaffer D.","year":"1988","journal-title":"Surgery"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.10.016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(02)01482\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/WJG.V25.I25.3123"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.942763"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0B013E328330680D"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/MSY.2001.109059"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1399\u20100012.2011.01579.X"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0B013E3283615DA1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PCL.2010.01.019"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0B013E328329CDC5"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.70400","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:03:59Z","timestamp":1792955039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/petr.70400"],"URL":"https:\/\/doi.org\/10.1111\/petr.70400","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70400"}}