{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:34:21Z","timestamp":1792956861671,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Aeromonas<\/jats:italic>\n                      species can cause bacteremia, but their epidemiology and clinical significance in pediatric liver transplant (LT) recipients are unclear. We evaluated the incidence, clinical features, management, and outcomes of\n                      <jats:italic>Aeromonas<\/jats:italic>\n                      bacteremia in this population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective observational study at a tertiary pediatric LT center from November 2005 to April 2023. Patients who underwent LT before 18\u2009years of age were reviewed, and cases of\n                      <jats:italic>Aeromonas<\/jats:italic>\n                      bacteremia were analyzed in detail.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 746 children who underwent LT, five episodes of\n                      <jats:italic>Aeromonas<\/jats:italic>\n                      bacteremia were identified. The incidence was 0.82 cases per 1000 person\u2010years. Median age at LT was 2\u2009years, and median interval from LT to bacteremia was 6\u2009years (range, 2\u2009months\u201324\u2009years). All patients were receiving maintenance immunosuppression without neutropenia or significant liver dysfunction, and none were receiving antibiotics, including trimethoprim\u2013sulfamethoxazole prophylaxis at the time of\n                      <jats:italic>Aeromonas<\/jats:italic>\n                      bacteremia. No patient had recent hepatobiliary procedures or biliary obstruction. All presented with fever; three had fever without source, and three reported freshwater exposure. Blood cultures yielded\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. hydrophila<\/jats:italic>\n                      <\/jats:styled-content>\n                      \/\n                      <jats:italic>caviae<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093) or\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. sobria<\/jats:italic>\n                      <\/jats:styled-content>\n                      (currently\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. veronii<\/jats:italic>\n                      <\/jats:styled-content>\n                      biovar sobria) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092). All isolates were susceptible to the empiric antibiotic regimens. Definitive therapy consisted of cefotaxime or cefepime, with or without metronidazole. All patients survived without progression to life\u2010threatening sepsis or relapse.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In pediatric LT recipients,\n                      <jats:italic>Aeromonas<\/jats:italic>\n                      bacteremia can occur late after transplantation under mild immunosuppression and without recognizable biliary risk factors. Early recognition and appropriate antibiotic therapy may contribute to favorable outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70407","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:51:00Z","timestamp":1784094660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Aeromonas<\/i>\n                    Bacteremia in Pediatric Liver Transplant Recipients: Case\u2010Based Experience of an Under\u2010Recognized Infection"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-1089","authenticated-orcid":false,"given":"Toshihiro","family":"Matsui","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-6943","authenticated-orcid":false,"given":"Masaki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-0262","authenticated-orcid":false,"given":"Kensuke","family":"Shoji","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties National Center for Child Health and Development  Tokyo Japan"},{"name":"Center for Postgraduate Education and Training National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6598-5187","authenticated-orcid":false,"given":"Takanori","family":"Funaki","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8718-6708","authenticated-orcid":false,"given":"Miyuki","family":"Jinguji","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Clinical Laboratory Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2441-5158","authenticated-orcid":false,"given":"Hajime","family":"Uchida","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4684-0446","authenticated-orcid":false,"given":"Akinari","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-7319","authenticated-orcid":false,"given":"Seisuke","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-0430","authenticated-orcid":false,"given":"Mureo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Organ Transplantation Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-8152","authenticated-orcid":false,"given":"Chikara","family":"Ogimi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00039-09"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198403000-00008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.5.1298"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2012.737474"},{"issue":"8","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255910","article-title":"Clinical Features and Outcome of \n                     Aeromonas sobria\n                   Bacteremia in Pediatric and Adult Patients With Hematologic Malignancies: A Single\u2010Center Retrospective Study in Peru","volume":"16","author":"Vadivelu J.","year":"2021","journal-title":"PLoS One"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091642"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"241","article-title":"Outcomes of Aeromonas Bacteremia in Patients With Different Types of Underlying Disease","volume":"33","author":"Lau S. M.","year":"2000","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02559.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06224-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/376629"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01700412"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2016.48.4.274"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.70407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:03:56Z","timestamp":1792955036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/petr.70407"],"URL":"https:\/\/doi.org\/10.1111\/petr.70407","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70407"}}