{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:22:58Z","timestamp":1787743378407,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early graft function after pediatric kidney transplantation (KT) may be influenced by perioperative hemodynamic and fluid management variables. However, previous studies have yielded conflicting results. This study aimed to evaluate the impact of perioperative factors on early graft function in pediatric KT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study included pediatric KT recipients from four academic centers in Turkiye and France. Early graft function was assessed using estimated glomerular filtration rate (eGFR) at postoperative day 7 and day 30. Delayed graft function (DGF) was defined as the need for dialysis within the first 7\u2009days post\u2010transplant. Mean arterial pressure (MAP) was calculated where reperfusion blood pressure data were available, and a sensitivity analysis accounting for transplant center was performed. Associations between perioperative variables and outcomes were evaluated using univariate and multivariate regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010seven patients were included (median age 154\u2009months; 45.4% female). DGF occurred in 11.3% of recipients. In multivariate analysis, no perioperative variable was independently associated with DGF. Longer cold ischemia time was independently associated with lower 7\u2010day eGFR (B\u2009=\u2009\u22120.05; 95% CI \u22120.10 to \u22120.01;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). At 30\u2009days, preemptive transplantation (B\u2009=\u2009\u221215.99; 95% CI \u221227.02 to \u22124.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and DGF (B\u2009=\u2009\u221236.94; 95% CI \u221258.39 to \u221215.50;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) were independently associated with lower eGFR; the preemptive association was attenuated after accounting for transplant center.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intraoperative hemodynamic parameters were not independently associated with DGF or early graft function. At day 7, early graft function was primarily associated with cold ischemia time, whereas at day 30 it was mainly associated with preemptive transplantation status and DGF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70414","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:28:58Z","timestamp":1787153338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do Perioperative Surgical Factors Affect Early Graft Function in Pediatric Kidney Transplantation?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-7942","authenticated-orcid":false,"given":"Muhammet Irfan","family":"Donmez","sequence":"first","affiliation":[{"name":"Department of Urology \u2013 Division of Pediatric Urology Istanbul University Istanbul Faculty of Medicine  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-2040","authenticated-orcid":false,"given":"Hakan Bahadir","family":"Haberal","sequence":"additional","affiliation":[{"name":"Department of Urology, Ankara Etlik City Hospital, Ministry of Health University of Health Sciences  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-6339","authenticated-orcid":false,"given":"Mehmet","family":"Tasdemir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u2013 Division of Pediatric Nephrology \u0130stinye University Faculty of Medicine  \u0130stanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1918-5143","authenticated-orcid":false,"given":"Alper","family":"Varman","sequence":"additional","affiliation":[{"name":"Department of General Surgery Necmettin Erbakan University Faculty of Medicine  Konya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Bakkaloglu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Istanbul University Istanbul Faculty of Medicine  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Dinckan","sequence":"additional","affiliation":[{"name":"Department of General Surgery \u0130stinye University Faculty of Medicine  \u0130stanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-0746","authenticated-orcid":false,"given":"Muhammed Emin","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Urology University of Health Sciences, Ankara City Hospital  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-2694","authenticated-orcid":false,"given":"Alicia","family":"L\u00f3pez\u2010Abad","sequence":"additional","affiliation":[{"name":"Department of Urology Virgen de la Arrixaca University Hospital  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0667-1468","authenticated-orcid":false,"given":"Alessio","family":"Pecoraro","sequence":"additional","affiliation":[{"name":"Unit of Urology and Renal Transplantation, Careggi Hospital University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3314-1892","authenticated-orcid":false,"given":"Beno\u00eet","family":"Mesnard","sequence":"additional","affiliation":[{"name":"Department of Urology and Transplantation Surgery Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Branchereau","sequence":"additional","affiliation":[{"name":"Department of Urology and Transplantation Surgery Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-2048","authenticated-orcid":false,"given":"Thomas","family":"Loubersac","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-9358","authenticated-orcid":false,"given":"Beatriz","family":"Ba\u00f1uelos Marco","sequence":"additional","affiliation":[{"name":"Department of Urology, Renal Transplant Division University Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Prudhomme","sequence":"additional","affiliation":[{"name":"Department of Urology and Kidney Transplantation Rangueil University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-7938","authenticated-orcid":false,"given":"Alberto","family":"Piana","sequence":"additional","affiliation":[{"name":"Department of Urology, San Luigi Gonzaga Hospital University of Turin  Orbassano, Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6753-7206","authenticated-orcid":false,"given":"Alberto","family":"Costa Silva","sequence":"additional","affiliation":[{"name":"Department of Urology S\u00e3o Jo\u00e3o University Hospital  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Territo","sequence":"additional","affiliation":[{"name":"Uro\u2010Oncology and Kidney Transplant Unit, Department of Urology at \u201cFundaci\u00f3 Puigvert\u201d Hospital Autonoma University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the European Association of Urology (EAU) Young Academic Urologists (YAU) Kidney Transplantation Working 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