{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:22:52Z","timestamp":1787743372026,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric combined liver\u2013kidney transplantation is uncommon, and evidence from Latin America is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a single\u2010center case series of four pediatric recipients who underwent combined liver\u2013kidney transplantation at a tertiary Latin\u2010American center. We summarize primary indications, perioperative course, early complications, and graft function at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Underlying diseases were primary hyperoxaluria type I (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), nephronophthisis type 3 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), and hepatorenal fibropolycystic disease\/autosomal recessive polycystic kidney disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091). Early complications included bacterial and viral infections, bleeding, and acute tubular necrosis. Three biopsy\u2010proven acute rejection episodes occurred (one moderate\u2013severe hepatic and two renal, including one late T\u2010cell\u2013mediated episode); all responded to treatment. At last follow\u2010up, all four patients were alive with functioning liver and kidney grafts. In three cases with long\u2010term follow\u2010up, the estimated glomerular filtration rate was 72, 64, and 48\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      with normal liver profiles; in one case with shorter institutional follow\u2010up, the estimated glomerular filtration rate was 74\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      with a transient liver profile abnormality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This first pediatric series from Latin America suggests that combined liver\u2013kidney transplantation is feasible and can achieve favorable long\u2010term patient and graft survival when candidates are appropriately selected and infectious and rejection complications are managed in a protocolized manner.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70419","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:43:18Z","timestamp":1787658198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Liver\u2013Kidney Transplantation in Pediatric Patients From Colombia: A Case Series"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-6111","authenticated-orcid":false,"given":"Alejandro","family":"Padilla\u2010Guzm\u00e1n","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Universidad Icesi  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-7716","authenticated-orcid":false,"given":"Sergio A.","family":"Ortega\u2010Gamboa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Universidad Icesi  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-757X","authenticated-orcid":false,"given":"Jessica Mar\u00eda","family":"Forero\u2010Delgadillo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Universidad Icesi  Cali Colombia"},{"name":"Pediatric Nephrology Service Fundaci\u00f3n Valle del Lili  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-2776","authenticated-orcid":false,"given":"Vanessa Amparo","family":"Ochoa\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Universidad Icesi  Cali Colombia"},{"name":"Pediatric Nephrology Service Fundaci\u00f3n Valle del Lili  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6231-321X","authenticated-orcid":false,"given":"Ana M.","family":"Portilla\u2010Buenaventura","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center Fundaci\u00f3n Valle del Lili  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-5808","authenticated-orcid":false,"given":"Camilo Jos\u00e9 Cuadros","family":"Mateus","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center Fundaci\u00f3n Valle del Lili  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8855-075X","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Botero\u2010Osorio","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology and Liver Transplant Service Fundaci\u00f3n Valle del Lili  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-0439","authenticated-orcid":false,"given":"Harry","family":"Pachajoa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Universidad Icesi  Cali Colombia"},{"name":"Medical Genetics Service Fundaci\u00f3n Valle del Lili  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-8922","authenticated-orcid":false,"given":"Jaime M.","family":"Restrepo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Universidad Icesi  Cali Colombia"},{"name":"Pediatric Nephrology Service Fundaci\u00f3n Valle del Lili  Cali 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