{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:22:58Z","timestamp":1787743378869,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2021A\u20102"],"award-info":[{"award-number":["2021A\u20102"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The morbidity and mortality after living donor liver transplantation (LDLT) in children with Alagille syndrome (AGS) are complex because of the multisystem involvement of the disease. Evidence on long\u2010term outcomes and donor selection remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study included 49 pediatric patients with AGS who underwent LDLT between 2001 and 2020 at eight institutions in Japan, Korea, and Turkey. Clinical characteristics, transplant indications, donor selection, posttransplant growth, renal function, and complications were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age at LDLT was 1.1\u2009years. Major indications for transplantation were severe growth failure (91.8%) and advanced liver disease with hepatic dysfunction. Based on donor evaluations, 11% of candidates were excluded due to genetic or anatomical concerns. The 5\u2010year patient and graft survival rates were 93.7% and 91.5%, respectively. LDLT before 2\u2009years of age was associated with significantly greater catch\u2010up in height and weight. Long\u2010term renal deterioration was observed, particularly beyond 15\u2009years after transplantation, and older age at LDLT was an independent predictor of lower long\u2010term estimated glomerular filtration rate. Cardiac anomalies were manageable with appropriate preoperative evaluation, whereas vasculopathies were observed after adolescence. A history of Kasai portoenterostomy did not significantly affect posttransplant outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LDLT provides excellent short\u2010 and long\u2010term outcomes in pediatric AGS. Timely LT may improve growth and preserve renal function before progressive multisystem complications become established. Long\u2010term surveillance and comprehensive donor evaluation remain essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70426","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:22:30Z","timestamp":1786526550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Outcomes of Living Donor Liver Transplantation in Children With Alagille Syndrome: Results From Vanguard Multicenter Study of International Living Donor Liver Transplantation Group"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-5548","authenticated-orcid":false,"given":"Yusuke","family":"Yanagi","sequence":"first","affiliation":[{"name":"Organ Transplantation Center, National Center for Child Health and Development  Tokyo Japan"},{"name":"Department of Pediatric Surgery Kyushu University Graduate School of Medicine  Fukuoka 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General and Transplant Surgery Jichii Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7464-8836","authenticated-orcid":false,"given":"Jiyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-2591","authenticated-orcid":false,"given":"Masaki","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Transplantation Kumamoto University Graduate School of Medical Sciences  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2553-2455","authenticated-orcid":false,"given":"Kazuya","family":"Hirukawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Transplantation Kumamoto 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