{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:23:00Z","timestamp":1787743380592,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Solid organ transplant (SOT) recipients face an increased risk of central nervous system (CNS) infections due to immunosuppression. The incidence of CNS infections in adult SOT recipients ranges from 0.4% to 10%, while it remains unknown in pediatric SOT recipients. Herein, we describe the incidence, clinical presentation, and outcomes of CNS infections in pediatric SOT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective cohort study that included 1628 first\u2010time SOT recipients \u2264\u200921\u2009years of age from 2003 to 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 23 patients with CNS infection representing an incidence of 2.3 per 1000 patient\u2010years. They occurred in 8\/400 (2%) heart; 7\/570 (1.2%) liver; 5\/220 (2.3%) lung; 2\/400 (0.5%) kidney, and 1\/38 (2.6%) multi\u2010organ transplant recipients. Documented symptoms included fever in 15\/23 (65%), altered mental status in 7\/23 (30%), nausea and emesis in 6\/23 (26%), and headache in 6\/23 (26%). Neuroimaging was performed in 15\/23 (65%) patients with CNS infection; 10\/15 (67%) had abnormal findings. Bacterial and fungal infections predominated, each accounting for 8\/23 (35%) cases, followed by viral infections in 7\/23 (30%) cases. Among patients with CNS infection, all\u2010cause mortality was observed in 9\/23 (39%), while it was 263\/1605 (16%) in those without a CNS infection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CNS infections in SOT recipients are rare and presentation can be non\u2010specific, though associated with a high mortality. These findings highlight the importance of maintaining clinical awareness of CNS infection in SOT recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70432","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:31:56Z","timestamp":1786951916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Central Nervous System Infections in Pediatric Solid Organ Transplant Recipients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0318-7961","authenticated-orcid":false,"given":"Amna","family":"AlSaihati","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0667-3826","authenticated-orcid":false,"given":"Kathleen E.","family":"Hosek","sequence":"additional","affiliation":[{"name":"Division of Quality, Department of Pediatrics Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Otero","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0436-551X","authenticated-orcid":false,"given":"Brandon H.","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0261-0406","authenticated-orcid":false,"given":"Carrie A.","family":"Mohila","sequence":"additional","affiliation":[{"name":"Department of Pathology Texas Children's Hospital  Houston Texas USA"},{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0049-1770","authenticated-orcid":false,"given":"David Moreno","family":"McNeill","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8562-1054","authenticated-orcid":false,"given":"Mini","family":"Michael","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-5518","authenticated-orcid":false,"given":"Krupa R.","family":"Mysore","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, 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