{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:22:57Z","timestamp":1787743377092,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n The study aimed to analyze the outcomes of\n TCR\u03b1\u03b2<\/jats:styled-content>\n \/\n CD19<\/jats:styled-content>\n \u2010depleted and T\u2010replete graft with post\u2010transplant cyclophosphamide (\n PTCY<\/jats:styled-content>\n ) in haploidentical hematopoietic stem cell transplantation (\n HSCT<\/jats:styled-content>\n ) in inborn errors of immunity (\n IEI<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n We performed a retrospective analysis of children from birth to 18\u2009years of age with\n IEI<\/jats:styled-content>\n who underwent haploidentical\n HSCT<\/jats:styled-content>\n between April 2009 and September 2024, with a minimum follow\u2010up period of 12\u2009months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 230 children with\n IEI<\/jats:styled-content>\n underwent\n HSCT<\/jats:styled-content>\n in the 15\u2010year period, where 105 (45%) underwent haploidentical\n HSCT<\/jats:styled-content>\n and were included in the analysis with a follow up period of 0.5 to 170\u2009months.\n TCR<\/jats:styled-content>\n \u2010\u03b1\u03b2\/\n CD19<\/jats:styled-content>\n \u2010depleted\n HSCT<\/jats:styled-content>\n was done in 65 (62%) children, while T\u2010replete graft with\n PTCY<\/jats:styled-content>\n was used in 40 (38%) children. There was no significant difference in engraftment rates, acute and chronic graft versus host disease rates between both the cohorts: T\u2010depleted group\u201489%, 8.6%, 12% respectively versus T\u2010replete group\u201485%, 15%, 17.5% respectively. The 5\u2010year overall survival was 62% (95%\n CI<\/jats:styled-content>\n : 48%\u201373%) in the\n TCR<\/jats:styled-content>\n \u2010\u03b1\u03b2\/\n CD<\/jats:styled-content>\n 19\u2010depleted cohort in comparison to 54% (95%\n CI<\/jats:styled-content>\n : 48% to 73%) in the\n PTCY<\/jats:styled-content>\n cohort. When the survival was compared in children less than 2\u2009years of age, it was 60% in the\n TCR<\/jats:styled-content>\n \u2010\u03b1\u03b2\/\n CD<\/jats:styled-content>\n 19 depleted cohort versus 37% in\n PTCY<\/jats:styled-content>\n cohort (p value of 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Survival was superior in the T depleted cohort as compared to the T replete group, with viral reactivation remaining a persisting challenge. Letermovir prophylaxis and memory cell add\u2010back would be potential strategies to improve survival.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/petr.70436","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:51:55Z","timestamp":1786945915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TCR<\/scp>\n \u2010\u03b1\u03b2\/\n CD<\/scp>\n 19 Depleted Graft Versus T Replete Graft With Post\u2010Transplant Cyclophosphamide in Children Undergoing Haploidentical Donor Hematopoietic Stem Cell Transplantation for Inborn Errors of Immunity: A Comparative Analysis From India"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-9107","authenticated-orcid":false,"given":"Anuraag Reddy","family":"Nalla","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9486-7219","authenticated-orcid":false,"given":"Kavitha","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-7226","authenticated-orcid":false,"given":"Vijayshree","family":"Muthukumar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minakshi","family":"Balwani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7561-8325","authenticated-orcid":false,"given":"Nithya","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0566-3153","authenticated-orcid":false,"given":"Krithika","family":"Krishnakumar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-8214","authenticated-orcid":false,"given":"Ramya","family":"Uppuluri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-4142","authenticated-orcid":false,"given":"Revathi","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation Apollo Hospitals Chennai Tamil Nadu 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