{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:09:31Z","timestamp":1791331771561,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Among the most abundant viruses in the human blood virome are anelloviruses, including\n                      <jats:italic>alpha<\/jats:italic>\n                      \u2010,\n                      <jats:italic>beta<\/jats:italic>\n                      \u2010, and\n                      <jats:italic>gammatorqueviruses<\/jats:italic>\n                      (TTV, TTMV, and TTMDV). Whether anelloviruses are transmitted through kidney transplantation at a young age and subsequently persist in their new host is unknown. This study investigates the dynamics and composition of the anellome in the blood of six pediatric donor\u2013recipient pairs, with monitoring beginning before transplantation and continuing until 2\u2009years after transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Donors were sampled once, before donation, while recipients were sampled before and multiple times after transplantation (median 6.5 samples). Quantitative PCR, rolling circle amplification, Illumina sequencing, and SCANellome V2 analysis were used to detect, characterize, and compare anellovirus presence in donors and recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, four out of six donors tested positive for TTV by quantitative anellovirus PCR, three of whom had sufficient viral loads to enable genomic comparison with their recipients. All recipients tested positive at baseline, five had a moderate viral load (&lt;\u200910\n                      <jats:sup>5<\/jats:sup>\n                      copies\/mL), and one had &gt;\u200910\n                      <jats:sup>9<\/jats:sup>\n                      copies of TTV DNA\/mL. This recipient was already immunosuppressed before transplantation, and only in this recipient was a donor\u2010derived anellovirus identified. This lineage was detected among 15 other lineages in the recipient and matched one of the four lineages identified in the donor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This finding demonstrates that anellovirus transmission from donor to recipient occurs in pediatric kidney transplantation. This may be associated with pre\u2010existing immunosuppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70448","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:24:13Z","timestamp":1788348253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transmission of Anellovirus From Kidney\u2010Donor to Pediatric Recipient: An Exploratory Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9848-4027","authenticated-orcid":false,"given":"Luna S.","family":"Klomp","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology Emma Children's Hospital, Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6817-4592","authenticated-orcid":false,"given":"Maarten G. 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M.","family":"Burggraaff","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute of Infection and Immunity  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreet","family":"Bakker","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute of Infection and Immunity  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Molier","sequence":"additional","affiliation":[{"name":"Department of Research, Blood\u2010Borne Infections Laboratory Sanquin Blood Supply  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-9542","authenticated-orcid":false,"given":"Anne L.","family":"Timmerman","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute of Infection and Immunity  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Deijs","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute of Infection and Immunity  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-9846","authenticated-orcid":false,"given":"Mariet","family":"Feltkamp","sequence":"additional","affiliation":[{"name":"Department of Research, Blood\u2010Borne Infections Laboratory Sanquin Blood Supply  Amsterdam the Netherlands"},{"name":"Department of Medical Microbiology &amp; Infection Prevention, Leiden University Center for Infectious Diseases Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"van der Hoek","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute of Infection and Immunity  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-6698","authenticated-orcid":false,"given":"Antonia H. M.","family":"Bouts","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Emma Children's Hospital, Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Amsterdam Institute of Infection and Immunity  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116608"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaa007"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-021-05192-x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00109-22"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.07.001"},{"key":"e_1_2_12_7_1","first-page":"10","article-title":"A Review on the Global Widespread of TTV Infection Among Humans Population","volume":"4","author":"Jarkasi N. 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