{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:03:39Z","timestamp":1790381019751,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL165301\u201001A1"],"award-info":[{"award-number":["1R01HL165301\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric\u2010onset pulmonary hypertension (PH) is a rare, progressive pulmonary vascular disease associated with high mortality. In cases unresponsive to pharmacological therapy with a severe cardiorespiratory phenotype, lung transplantation (LT) remains the final treatment option. Although LT for pediatric PH is considered a procedure with elevated risk, it has been successfully performed in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      A 3\u2010year\u2010old boy underwent uncomplicated LT for fulminant\n                      <jats:italic>TBX4<\/jats:italic>\n                      \u2010associated PH and developed hyperacute allograft failure requiring plasmapheresis, augmentation of immunosuppression, and the use of a monoclonal complement inhibitor. Despite extensive treatment the patient died 46\u2009days after LT. Retrospective analysis of the serum sample taken at time of transplant prior to reperfusion was positive for six non\u2010histocompatibility antibodies: Sjogren syndrome antigen B, thyroglobulin, glutathione S\u2010transferase Theta\u20101, colony stimulating factor 2, intracellular adhesion molecule 1, and interferon gamma that were not present in other pediatric thoracic transplant recipients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hyperacute allograft rejection is extremely rare in LT recipients and its occurrence in this patient implies the need for further characterization of non\u2010HLA antibody\u2010associated LT rejection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70457","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:25:01Z","timestamp":1790169901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010\n                    <scp>HLA<\/scp>\n                    Antibody\u2010Associated Hyperacute Allograft Rejection Following Lung Transplantation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2340-4513","authenticated-orcid":false,"given":"Justyna A.","family":"Karolak","sequence":"first","affiliation":[{"name":"Chair and Department of Genetics and Pharmaceutical Microbiology Poznan University of Medical Sciences  Poznan Poland"},{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas 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College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-8133","authenticated-orcid":false,"given":"Esra Y\u0131ld\u0131z","family":"B\u00f6l\u00fckba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"McHugh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas USA"},{"name":"Division of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Nicholas","sequence":"additional","affiliation":[{"name":"Section of Allergy and Immunology, Department of Pediatrics 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