{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:10:58Z","timestamp":1769825458595,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Arkansas' 2003 Centers for Disease Control Bioterrorism Cooperative Agreement"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nursing"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Smallpox vaccination has been associated with notable side effects and adverse events. This study assessed the frequency of each among public health workers immunized during the 2003 Arkansas civilian smallpox vaccination campaign to allow individuals and policymakers to make informed decisions whether repeat vaccination, as recommended in 10\u2010year intervals, should be considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Sample<\/jats:title><jats:p>This descriptive study summarizes postvaccination surveillance data for all civilians receiving smallpox vaccine (Dryvax) in Arkansas in 2003.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measures<\/jats:title><jats:p>Rates of side effects and adverse events were determined. Vaccinia\u2010specific antibody titers among a subset of public health response team members were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1,124 vaccine recipients, 87% had a major take response. Substantial symptomatology, a 2% adverse event rate, a 0.5% hospitalization rate, and zero inadvertent transmission following vaccination were observed. Vaccinia\u2010specific antibody titers increased on average 9\u2010fold from 2.21*10<jats:sup>2<\/jats:sup> to 2.16*10<jats:sup>3<\/jats:sup> one\u00a0month after vaccination. We found no association of age, sex, or racial subgroups with adverse events, hospitalizations, a lower take response rate, or lower postvaccination antibody titers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prominent side effect profiles and adverse events among study participants seem to support individual and institutional reluctance to vaccinate civilians in the absence of smallpox reemergence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phn.12208","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T05:56:52Z","timestamp":1433483812000},"page":"129-138","source":"Crossref","is-referenced-by-count":13,"title":["Vaccination\u2010Related Side Effects, Humoral Immunity, and Adverse Events during the Civilian Smallpox Vaccination Campaign, Arkansas, 2003"],"prefix":"10.1111","volume":"33","author":[{"given":"Dirk","family":"Haselow","sequence":"first","affiliation":[{"name":"Arkansas Department of Health Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/428731"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/368093"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.21.2734"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.053"},{"key":"e_1_2_6_6_1","first-page":"15","volume-title":"Epidemiology and prevention of vaccine\u2010preventable diseases","author":"CDC","year":"2011"},{"key":"e_1_2_6_7_1","unstructured":"CDC. (2008).CDC interim guidance for revaccination of eligible persons who participated in the US civilian smallpox preparedness and response program. Retrieved fromhttp:\/\/emergency.cdc.gov\/agent\/smallpox\/revaxmemo.asp"},{"key":"e_1_2_6_8_1","unstructured":"CDC. (2003).Update: cardiac\u2010related events during the civilian smallpox vaccination program\u2013United States 2003. Morbidity and Mortality Weekly Report.52(21) 492\u2013496."},{"key":"e_1_2_6_9_1","volume-title":"Smallpox and its eradication","author":"Fenner F.","year":"1988"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013431"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020534"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.24.3295"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004913.pub2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/524747"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/524749"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/374564"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022500"},{"key":"e_1_2_6_19_1","first-page":"1","article-title":"Who will pay for the adverse events resulting from smallpox vaccination? Liability and compensation issues","volume":"788","author":"Strongin R. J.","year":"2003","journal-title":"NHPF Issue Brief"}],"container-title":["Public Health Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphn.12208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/phn.12208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:03:48Z","timestamp":1696190628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/phn.12208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,4]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/phn.12208"],"URL":"https:\/\/doi.org\/10.1111\/phn.12208","archive":["Portico"],"relation":{},"ISSN":["0737-1209","1525-1446"],"issn-type":[{"value":"0737-1209","type":"print"},{"value":"1525-1446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,4]]}}}