{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:39:41Z","timestamp":1756895981500,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Nursing"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Newborn screening (NBS) is a public health program that detects genetic conditions in neonates enabling treatment before clinical symptoms manifest. Severe combined immune deficiency (SCID) is a primary immune deficiency found in the absence of functioning T and B lymphocytes. Hematopoietic cell transplantation is a potentially curative treatment if received within the first 42\u00a0months of life; without treatment, this condition is fatal in the first 2\u00a0years of life due to severe opportunistic infections. SCID was added to the recommended uniform panel of conditions for inclusion in state NBS programs in 2010. This manuscript examines the societal costs and benefits of NBS for SCID in Arkansas and implications to health services and social welfare. Total cost per year of all NBS for SCID and resulting early treatment for one patient with SCID in Arkansas is estimated at $1,078,714. Cost of late treatment of one patient with SCID is estimated at $1.43 million. Based on an expected diagnosis of one patient per year in Arkansas, this results in an estimated net cost savings for NBS for SCID in Arkansas of $351,286 per year. Based on cost\u2010effectiveness analysis, NBS for SCID in Arkansas is cost\u2010effective, with higher societal benefit than cost.<\/jats:p>","DOI":"10.1111\/phn.12614","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T02:24:31Z","timestamp":1554344671000},"page":"541-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Societal value of newborn screening for severe combined immune deficiency in Arkansas: An economic analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-0127","authenticated-orcid":false,"given":"Laura H.","family":"Hays","sequence":"first","affiliation":[{"name":"College of Nursing University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1353\/hcr.0.0009"},{"key":"e_1_2_6_3_1","unstructured":"Bonilla F.(2016).UpToDate: Hematopoietic cell transplantation for primary immunodeficiency. Available fromhttp:\/\/www.uptodate.com\/contents\/hematopoietic-cell-transplantation-for-primary-immunodeficiency?source=search_result&search=SCID&selectedTitle=12%7E120[last accessed 9 February 2016]."},{"key":"e_1_2_6_4_1","unstructured":"Burwell S.(2016).Secretary of Health and Human Services in a letter to J. Bocchini Jr. Chairperson Advisory Committee of Heritable Disorders in Newborns and Children."},{"key":"e_1_2_6_5_1","unstructured":"Centers for Disease Control and Prevention. (2016).Severe combined immunodeficiency. Available fromhttp:\/\/www.cdc.gov\/newbornscreening\/scid.html[last accessed 6 February 2016]."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.07.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.02.004"},{"key":"e_1_2_6_8_1","unstructured":"CodeMap. (2016). Available fromhttps:\/\/www.codemap.com\/cpt_print.cfm?cpt_code[last accessed 14 March 2016]."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0029-0"},{"key":"e_1_2_6_10_1","article-title":"Arkansas Department of Health Newborn Screening Lab Manager","author":"Himstedt L.","year":"2016","journal-title":"Personal"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000221"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.05.013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.9132"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3181eedf01"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8485-4"},{"key":"e_1_2_6_16_1","first-page":"23","article-title":"United States Preventive Services Task Force. Expanding newborn screening: Process, policy, and priorities","volume":"38","author":"Moyer V.","year":"2008","journal-title":"Hastings Center Report"},{"key":"e_1_2_6_17_1","unstructured":"NewSTEPs Data Repository. (2018).Screening methodologies and targets report. 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