{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:45:05Z","timestamp":1768481105886,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002992","name":"Department for International Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Nursing"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Due to the absence of a licenced vaccine or drug for treatment of Ebola patients during the 2014\u20132016 West Africa outbreak, frontline nurses were at increased risk of exposure. Hence, they were prioritized to participate in clinical trials to receive experimental therapeutics. To our knowledge no study has explored the nurses' experiences of their decision\u2010making process when volunteering in clinical trials using unproven agents, which is the purpose of this qualitative study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study, part of a larger Ebola study, thematically analyzed the interview data of nine nurses recruited from Sierra Leone, Guinea and Liberia; of which four joined a convalescent plasma trial and five a vaccine trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In their decision\u2010making process to partake in a clinical trial, nurses identified two distinct decision points: the <jats:italic>initial commitment<\/jats:italic> followed by the <jats:italic>point of no return<\/jats:italic> when they presented themselves to participate. Each of these decisions were influenced by risk versus benefits calculations, and contextual factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results showed the need for more health education and communication around the unproven agents in order for nurses to make informed decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phn.12822","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T01:20:05Z","timestamp":1603848005000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nurses' experiences of their decision\u2010making process when participating in clinical trials during the 2014\u20132016 West African Ebola crisis"],"prefix":"10.1111","volume":"38","author":[{"given":"David","family":"Nguyen","sequence":"first","affiliation":[{"name":"Jewish General Hospital Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-7058","authenticated-orcid":false,"given":"Antonia","family":"Arnaert","sequence":"additional","affiliation":[{"name":"Ingram School of Nursing McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Pringle","sequence":"additional","affiliation":[{"name":"Ingram School of Nursing McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Ponzoni","sequence":"additional","affiliation":[{"name":"Ingram School of Nursing McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sekou","family":"Kouyat\u00e9","sequence":"additional","affiliation":[{"name":"LASAG (Laboratoire Socio\u2010anthropologique de la Guin\u00e9e) Conakry Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahal","family":"Fansia","sequence":"additional","affiliation":[{"name":"School of Medicine McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elys\u00e9e","family":"Nouvet","sequence":"additional","affiliation":[{"name":"School of Health Studies Western University London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"81","article-title":"In the shadow of tomorrow: Ebola vaccine research in Liberia","volume":"5","author":"Alenichev A.","year":"2018","journal-title":"Medicine Anthropology Medicine"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix558"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix657"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2007.04569.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3799-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0206"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00065-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1411250"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043659605278935"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2311.171206"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.02.046"},{"issue":"41","key":"e_1_2_9_13_1","first-page":"1110","article-title":"Knowledge, attitudes, and practices related to Ebola virus disease at the end of a national epidemic \u2013 Guinea, August 2015","volume":"66","author":"Jalloh M. 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