{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:18:50Z","timestamp":1788221930031,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30521"],"award-info":[{"award-number":["2023JJ30521"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Nursing"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer mortality. HCC has high morbidity, high mortality, and low survival rates. Screening is one of the most significant methods of lowering incidence and death while also increasing survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to identify the facilitators and barriers to participation in HCC screening among high\u2010risk populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive and systematic search was undertaken in PubMed, Web of Science, MEDLINE, EMBACE, EBSCOhost and the Cochrane Library. A combination of synonyms of the keywords including HCC, screening, factors and adherence were used for searching. Studies addressing the facilitators and barriers to HCC screening compliance in at\u2010risk individuals were included. Data were synthesized using Review Manager version 5.4. A random\/fixed effects model meta\u2010analysis was performed to estimate the pooled data and expressed with odds ratio (OR) and 95% confidence interval (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of seven articles met the inclusion criteria. Qualitative (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and quantitative (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) studies using various types of surgery were conducted. The most commonly mentioned barriers were insufficient knowledge and awareness of HCC screening, unawareness of the necessity for early detection of HCC and lack of physician recommendation. A meta\u2010analysis of seven studies showed that individuals with a family history of HCC increased screening uptake by nearly three times (OR: 2.69, 95% CI: 1.93, 3.75). Other most frequently reported facilitators include age, education level, and perceived risk et\u00a0al.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many barriers to HCC screening were found. Meanwhile, this review points out that improving the awareness of high\u2010risk populations toward HCC screening is expected to enhance compliance, thereby promoting early diagnosis of liver cancer, reducing mortality, and alleviating the burden of HCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phn.13298","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T06:55:31Z","timestamp":1710226531000},"page":"476-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors affecting the compliance of hepatocellular carcinoma screening among high\u2010risk populations: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9549-2556","authenticated-orcid":false,"given":"Ge\u2010hui","family":"Feng","sequence":"first","affiliation":[{"name":"Department of International and Humanistic Nursing Hunan Science Popularization Education Base School of Nursing Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010qian","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing Hunan Science Popularization Education Base School of Nursing Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010hao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing Hunan Science Popularization Education Base School of Nursing Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing Hunan Science Popularization Education Base School of Nursing Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing Hunan Science Popularization Education Base School of Nursing Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010xue","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing Hunan Science Popularization Education Base School of Nursing Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010ru","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing Hunan Science Popularization Education Base School of Nursing Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing Hunan Science Popularization Education Base School of Nursing Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Hunan Province Key Laboratory of Tumor Cellular &amp; 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