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By addressing these areas, the article contributes to the decision\u2010making for the design and delivery of effective strategies to improve the health outcomes among marginalized populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The findings underscore the importance of flexibility and active participant engagement, cultivating strong relationships with community partners, utilizing technology and social media, and fostering a diverse research team that represents the heterogeneity of youth experiencing homelessness across race\/ethnicity, gender identity, sexual orientation, and lived experiences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These recommendations aim to enhance participant access, engagement, and retention, while promoting rigorous research and meaningful study outcomes for YEH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/phn.13314","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T14:41:25Z","timestamp":1712241685000},"page":"806-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lessons learned from conducting a community\u2010based, nurse\u2010led HIV prevention trial with youth experiencing homelessness: Pivots and pitfalls"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-226X","authenticated-orcid":false,"given":"Diane M.","family":"Santa Maria","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center at Houston Cizik School of Nursing  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-7096","authenticated-orcid":false,"given":"Higinio","family":"Fernandez\u2010Sanchez","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston Cizik School of Nursing  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adey","family":"Nyamathi","sequence":"additional","affiliation":[{"name":"Founding Dean and Distinguished Professor School of Nursing at UC Irvine  Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerita","family":"Lightfoot","sequence":"additional","affiliation":[{"name":"Oregon Health Science Center, School of Public Health  Portland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen","family":"Quadri","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Baylor College of Medicine Medical Director of the Harris Health System Healthcare for the Homeless Program  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Paul","sequence":"additional","affiliation":[{"name":"Chief of Service, Retrovirology and Global Health Texas Children's Hospital\/Baylor College of Medicine  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Torres","family":"Jones","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston Cizik School of Nursing  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1556264619892707"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10488\u2010014\u201002010;9"},{"key":"e_1_2_7_4_1","unstructured":"Buck L. 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