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This clinical trial was an open\u2010label, single\u2010center study with 42 perennial allergic rhinitis subjects. Following laser irradiation in the nasal cavity with a laser irradiation system, the efficacy at weeks 1 through 4 was determined. The symptoms were scored with four parameters (nasal obstruction, rhinorrhea, sneezing and itching) before and after illumination of the laser, and the total score was recorded. A survey of Rhinoconjunctivitis Quality of Life Questionnaire (<jats:styled-content style=\"fixed-case\">RQLQ<\/jats:styled-content>) was conducted by patients before and after treatment. Following treatment, significant improvement in the clinical symptoms of nasal obstruction (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), rhinorrhea (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.005), sneezing (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.001) and itching (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.003) was reported by 68% of perennial allergic rhinitis patients. The overall <jats:styled-content style=\"fixed-case\">RQLQ<\/jats:styled-content> scores significantly improved by 45% from the baseline with the treatment after 4\u00a0weeks. These results indicate that phototherapy is an effective modality for treating perennial allergic rhinitis and is another option in the steroid\u2010free management of immune\u2010mediated mucosal diseases.<\/jats:p>","DOI":"10.1111\/php.12032","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T19:38:00Z","timestamp":1355859480000},"page":"751-757","source":"Crossref","is-referenced-by-count":15,"title":["A Comparative Pilot Study of Symptom Improvement Before and After Phototherapy in Korean Patients with Perennial Allergic Rhinitis"],"prefix":"10.1111","volume":"89","author":[{"given":"Heung\u2010Man","family":"Lee","sequence":"first","affiliation":[{"name":"Medical Devices Clinical Trial Center Guro Hospital Korea University Seoul Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery College of Medicine Korea University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Sik","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Statistics College of Natural Sciences Sungshin Women's University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Medical Devices Clinical Trial Center Guro Hospital Korea University Seoul Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery College of Medicine Korea University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Devices Clinical Trial Center Guro Hospital Korea University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Keon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics College of Natural Sciences Sungshin Women's University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp;Neck Surgery Inha University Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Medical Devices Clinical Trial Center Guro Hospital Korea University Seoul Korea"},{"name":"Department of Medical Sciences Graduate School of Medicine Korea University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1592"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2009.30.3230"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.1935.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.68"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440106"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8205"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465810374610"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21042"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(00)19031-7"},{"issue":"583","key":"e_1_2_6_13_1","first-page":"e1","article-title":"Reversal of atopic dermatitis with narrow\u2010band UVB phototherapy and biomarkers for therapeutic response","volume":"128","author":"Tintle S.","year":"2011","journal-title":"J. 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