{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:41:11Z","timestamp":1780634471210,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>is currently thought to be carcinogenic because, similar to<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>, it induces the formation of cyclobutane pyrimidine dimers (<jats:styled-content style=\"fixed-case\">CPD<\/jats:styled-content>s). Various drugs have been reported to cause photosensitive drug eruptions as an adverse effect. Although the precise mechanism of photosensitive drug eruption remains to be elucidated, it is generally accepted that free radicals and other reactive molecules generated<jats:italic>via<\/jats:italic><jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010irradiated drugs play important roles in the pathogenesis of photosensitive drug eruptions. The waveband of concern for photo\u2010reactive drugs is<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010visible light, but some extend into the<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>region. We tested whether photosensitive drugs could enhance<jats:styled-content style=\"fixed-case\">CPD<\/jats:styled-content>formation after<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>exposure by using isolated<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>in the presence of several reported photosensitive drugs using high\u2010performance liquid chromatography. We found that the diuretic agent hydrochlorothiazide (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>) significantly enhanced the production of<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>dimers over a wide range of<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>. Furthermore, we investigated whether<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>plus<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>could enhance<jats:styled-content style=\"fixed-case\">CPD<\/jats:styled-content>production in xeroderma pigmentosum model mice defective in nucleotide excision repair. Immunofluorescence studies showed that<jats:styled-content style=\"fixed-case\">CPD<\/jats:styled-content>formation in the skin significantly increased after 365\u00a0nm narrow\u2010band<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>irradiation in the presence of<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>, compared with that in wild\u2010type mice.<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>could be used with caution because of its enhancement of<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010induced<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>damage.<\/jats:p>","DOI":"10.1111\/php.12048","type":"journal-article","created":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T10:14:49Z","timestamp":1358676889000},"page":"649-654","source":"Crossref","is-referenced-by-count":52,"title":["Hydrochlorothiazide Enhances<scp>UVA<\/scp>\u2010Induced<scp>DNA<\/scp>Damage"],"prefix":"10.1111","volume":"89","author":[{"given":"Makoto","family":"Kunisada","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Masaki","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Morinaga","sequence":"additional","affiliation":[{"name":"Institute for Integrated Cell\u2010Material Sciences (iCeMS), Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Nakano","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flandiana","family":"Yogianti","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"},{"name":"Department of Dermatology and Venereology, Faculty of Medicine Gadjah Mada University Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Okunishi","sequence":"additional","affiliation":[{"name":"Institute for Integrated Cell\u2010Material Sciences (iCeMS), Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Institute for Integrated Cell\u2010Material Sciences (iCeMS), Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0031-6997(24)01501-1","article-title":"Cutaneous drug reactions","volume":"53","author":"Svensson C. 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