{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:00:45Z","timestamp":1791259245205,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) radiation damages human skin and causes skin diseases such as epidermal hyperplasia, sunburn, inflammatory responses and photoaging. Photoaging is associated with upregulated matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>) expression and downregulated collagen synthesis. Fucosterol, which is isolated from marine brown algae, has been reported to possess antioxidant and anticancer activities; however, its effects on photoaging are unknown. This study assessed the effects of fucosterol on photoaging and investigated its mechanisms of action in <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010irradiated immortalized human keratinocytes (HaCaT) by enzyme\u2010linked immunosorbent assay, semi\u2010quantitative reverse transcription\u2010polymerase chain reaction, Western blot analysis and 2\u2032,7\u2032\u2010dichlorofluorescein diacetate assay. Our results showed that fucosterol attenuated <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> and inflammatory cytokine expression by deactivating mitogen\u2010activated protein kinases (<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>s) induced by reactive oxygen species. Fucosterol also increased type\u2010I procollagen and antioxidant enzyme expression. Taken together, fucosterol regulates the expression of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s and type\u2010I procollagen in <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010irradiated HaCaT by modulating <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>, suggesting it as a potential candidate for prevention and treatment of skin aging.<\/jats:p>","DOI":"10.1111\/php.12061","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T10:41:12Z","timestamp":1361270472000},"page":"911-918","source":"Crossref","is-referenced-by-count":87,"title":["Fucosterol Inhibits Matrix Metalloproteinase Expression and Promotes Type\u20101 Procollagen Production in <scp>UVB<\/scp>\u2010induced HaCaT Cells"],"prefix":"10.1111","volume":"89","author":[{"given":"Myung\u2010Suk","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biotechnology College of Life Science and Biotechnology Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u2010Hui","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science and Engineering Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science and Engineering Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Kwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology College of Life Science and Biotechnology Yonsei University Seoul Korea"},{"name":"Department of Biomaterials Science and Engineering Yonsei University Seoul 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