{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:39:28Z","timestamp":1790674768524,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pterins, heterocyclic compounds widespread in biological systems, accumulate in the skin of patients suffering from vitiligo, a chronic depigmentation disorder. Pterins have been previously identified as good photosensitizers under <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A irradiation. In this work, we have investigated the ability of pterin (Ptr), the parent compound of oxidized pterins, to photosensitize the oxidation of tyrosine (Tyr) in aqueous solutions. Tyr is an important target in the study of the photodynamic effects of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A radiation because it is oxidized by singlet oxygen (<jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>) and plays a key role in polymerization and cross\u2010linking of proteins. Steady <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A irradiation of solutions containing Ptr and Tyr led to the consumption of Tyr and dissolved O<jats:sub>2<\/jats:sub>, whereas the Ptr concentration remained unchanged. Concomitantly, hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) was produced. By combining different analytical techniques, we could establish that the mechanism of the photosensitized process involves an electron transfer from Tyr to the triplet excited state of Ptr. Mass spectrometry, chromatography and fluorescence were used to analyze the photoproducts. In particular, oxygenated and dimeric compounds were identified.<\/jats:p>","DOI":"10.1111\/php.12099","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T06:50:50Z","timestamp":1368859850000},"page":"1448-1455","source":"Crossref","is-referenced-by-count":41,"title":["Oxidation of Tyrosine Photoinduced by Pterin in Aqueous Solution"],"prefix":"10.1111","volume":"89","author":[{"given":"Carolina","family":"Casta\u00f1o","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Facultad de Ciencias Exactas Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Universidad Nacional de La Plata CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"D\u00e1ntola","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Facultad de Ciencias Exactas Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Universidad Nacional de La Plata CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Oliveros","sequence":"additional","affiliation":[{"name":"Laboratoire des Interactions Mol\u00e9culaires R\u00e9activit\u00e9 Chimique et Photochimique (IMRCP) UMR 5623\u2010CNRS\/UPS Universit\u00e9 Toulouse III (Paul Sabatier) Toulouse C\u00e9dex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Facultad de Ciencias Exactas Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Universidad Nacional de La Plata CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Lorente","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Facultad de Ciencias Exactas Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Universidad Nacional de La Plata CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1149","article-title":"Phosphorescence analysis of the triplet state of pterins in connection with their photoreceptor function in biochemical systems","volume":"61","author":"Neverov K. V.","year":"1996","journal-title":"Biochemistry (Moscow)"},{"key":"e_1_2_6_3_1","first-page":"1117","article-title":"Photosensitization of singlet oxygen formation by pterins and flavins. Time\u2010resolved studies of oxygen phosphorescence under laser excitation","volume":"64","author":"Egorov S. Y.","year":"1999","journal-title":"Biochemistry (Moscow)"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar050151c"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1351\/PAC-CON-10-08-22"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cp41476g"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610100104"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8128228"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.54.070185.003501"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.00220.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6727"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/b913095k"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00817-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.155"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2013.01.008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.044"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05164d"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/pteridines.2011.22.1.111"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1998.tb02499.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2002)0760035SOMPOE2.0.CO2"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(93)90109-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9526037"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(84)07026-9"},{"key":"e_1_2_6_24_1","first-page":"85","volume-title":"Photochemical Technology (Translated by D. F. Ollis and N. Serpone)","author":"Braun A. M.","year":"1991"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac200476122105"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/20.4.470"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456327301000125"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cp02912b"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4601(2000)32:4<231::AID-KIN5>3.0.CO;2-Y"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200490135"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.06.011"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(96)07451-9"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/b209993d"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja075367j"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00806554"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2004.tb00061.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1979.tb07786.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.555965"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(91)80212-Z"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00349a007"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1973.tb06449.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00461a055"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.555739"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1978.tb07009.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31395-4"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116531"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022525909128"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00966a019"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf200277r"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53581-X"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-003-0014-z"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1999.tb07980.x"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphp.12099","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.12099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:42:00Z","timestamp":1695987720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.12099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/php.12099"],"URL":"https:\/\/doi.org\/10.1111\/php.12099","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}