{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:39:43Z","timestamp":1782502783685,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T00:00:00Z","timestamp":1375488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biopterin (Bip) and its photoproducts 6\u2010formylpterin (Fop) and 6\u2010carboxypterin (Cap) accumulate in the skin of patients suffering from vitiligo, a chronic depigmentation disorder where the protection against <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> radiation fails because of the lack of melanin. These compounds absorb in the <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A inducing a potential photosensitizing action that can cause damage to <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> and other biomolecules. In this work, we have investigated the capability of these pterin derivatives (Pt) to act as photosensitizers under <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A irradiation for the degradation of 2\u2032\u2010deoxyadenosine 5\u2032\u2010monophosphate (5\u2032\u2010<jats:styled-content style=\"fixed-case\">dAMP<\/jats:styled-content>) in aqueous solutions, as model <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> target. Steady\u2010state and time\u2010resolved experiments were performed and the effect of <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> was evaluated. The results showed that photosensitized degradation of 5\u2032\u2010<jats:styled-content style=\"fixed-case\">dAMP<\/jats:styled-content> was only observed under acidic conditions, and a mechanistic analysis revealed the participation of the triplet excited state of the pterin derivatives (<jats:sup>3<\/jats:sup><jats:styled-content style=\"fixed-case\"><jats:roman>Pt<\/jats:roman><\/jats:styled-content>*) by electron transfer yielding the corresponding pair of radical ions (<jats:styled-content style=\"fixed-case\"><jats:roman>Pt<\/jats:roman><\/jats:styled-content><jats:sup>\u2022\u2212<\/jats:sup> and 5\u2032\u2010<jats:styled-content style=\"fixed-case\">dAMP<\/jats:styled-content><jats:sup>\u2022+<\/jats:sup>), with successive photosensitizer recovery by electron transfer from <jats:styled-content style=\"fixed-case\"><jats:roman>Pt<\/jats:roman><\/jats:styled-content><jats:sup>\u2022\u2212<\/jats:sup> to <jats:styled-content style=\"fixed-case\"><jats:roman>O<\/jats:roman><\/jats:styled-content><jats:sub>2<\/jats:sub>. Finally, 5\u2032\u2010<jats:styled-content style=\"fixed-case\">dAMP<\/jats:styled-content><jats:sup>\u2022+<\/jats:sup> participates in subsequent reactions to yield degradation products.<\/jats:p>","DOI":"10.1111\/php.12134","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T14:49:03Z","timestamp":1373381343000},"page":"1456-1462","source":"Crossref","is-referenced-by-count":12,"title":["Type I Photosensitization of 2\u2032\u2010deoxyadenosine 5\u2032\u2010monophosphate (5\u2032\u2010<scp>dAMP<\/scp>) by Biopterin and its Photoproduct Formylpterin"],"prefix":"10.1111","volume":"89","author":[{"given":"Mariana P.","family":"Serrano","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP) CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio D.","family":"Borsarelli","sequence":"additional","affiliation":[{"name":"Laboratorio de Cin\u00e9tica y Fotoqu\u00edmica (LACIFO) Centro de Investigaciones y Transferencia de Santiago del Estero (CITSE\u2010CONICET) Universidad Nacional de Santiago del Estero (UNSE) Santiago del Estero Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP) CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/b201025a"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.08.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(01)00206-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.09.012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/B504573H"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol801514v"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1sc00088h"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(98)00142-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1991.tb02071.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar050151c"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1351\/PAC-CON-10-08-22"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.00220.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6727"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/b913095k"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)83082-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2008.00450.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9620161"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00722-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7513com"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/b707312g"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja075367j"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cp41476g"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp1061336"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2003.10.018"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2009.12.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.06.011"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(96)07451-9"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/b202114e"},{"key":"e_1_2_6_30_1","first-page":"1149","article-title":"Phosphorescence analysis of the triplet state of pterins in connection with their photoreceptor function in biochemical systems","volume":"61","author":"Neverov K. 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