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This drug is indicated in psychiatry primarily for the treatment of schizophrenia and other schizoaffective disorders. Levomepromazine's particular sedative properties make it especially fit for use in psychiatric intensive care. Nevertheless, it is photolabile under <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010B light in aerobic conditions resulting in the formation of its sulfoxide. The <jats:styled-content style=\"fixed-case\">LPZ<\/jats:styled-content> photochemistry in acetonitrile (<jats:styled-content style=\"fixed-case\"><jats:roman>MeCN<\/jats:roman><\/jats:styled-content>) is completely different from that in methanol (<jats:styled-content style=\"fixed-case\"><jats:roman>MeOH<\/jats:roman><\/jats:styled-content>) and phosphate buffer solutions (<jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> pH<\/jats:styled-content>\u00a0=\u00a07.4). The major photoproduct in <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:roman>MeOH<\/jats:roman><\/jats:styled-content> under aerobic conditions is levomepromazine sulfoxide (<jats:styled-content style=\"fixed-case\">LPZSO<\/jats:styled-content>), although the amount is considerably higher in the aqueous environment. The corresponding main photoproduct in <jats:styled-content style=\"fixed-case\"><jats:roman>MeCN<\/jats:roman><\/jats:styled-content> could not be characterized. The destruction quantum yields of <jats:styled-content style=\"fixed-case\">LPZ<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:roman>MeOH<\/jats:roman><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:roman>MeCN<\/jats:roman><\/jats:styled-content> are 0.13, 0.02 and &lt;10<jats:sup>\u22123<\/jats:sup>, respectively. It is further demonstrated that <jats:styled-content style=\"fixed-case\">LPZSO<\/jats:styled-content> does not form by the reaction of singlet oxygen with ground\u2010state <jats:styled-content style=\"fixed-case\">LPZ<\/jats:styled-content>. This oxidation product is actually produced by the reaction of the cation radical of <jats:styled-content style=\"fixed-case\">LPZ<\/jats:styled-content> (LPZ\u00b7<jats:sup>+<\/jats:sup>) with molecular oxygen. This cation radical in turn, is produced by an electron transfer process between the <jats:sup>3<\/jats:sup><jats:styled-content style=\"fixed-case\">LPZ<\/jats:styled-content>* and ground\u2010state molecular oxygen.<\/jats:p>","DOI":"10.1111\/php.12147","type":"journal-article","created":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T15:58:45Z","timestamp":1375545525000},"page":"1479-1489","source":"Crossref","is-referenced-by-count":2,"title":["Photooxidation Mechanism of Levomepromazine in Different Solvents"],"prefix":"10.1111","volume":"89","author":[{"given":"Luis E.","family":"Pi\u00f1ero\u2010Santiago","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Puerto Rico at Humacao Humacao PR"},{"name":"Instituto de Tecnolog\u00eda Qu\u00edmica UPV\u2010CSIC Universitat Polit\u00e8cnica de Val\u00e8ncia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Puerto Rico at Humacao Humacao PR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Lhiaubet\u2010Vallet","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00eda Qu\u00edmica UPV\u2010CSIC Universitat Polit\u00e8cnica de Val\u00e8ncia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Trzcionka","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00eda Qu\u00edmica UPV\u2010CSIC Universitat Polit\u00e8cnica de Val\u00e8ncia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolando","family":"Oyola","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Puerto Rico at Humacao Humacao PR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Puerto Rico at Humacao Humacao PR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaysika","family":"Leguill\u00fa","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Puerto Rico at Humacao Humacao PR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00eda Qu\u00edmica UPV\u2010CSIC Universitat Polit\u00e8cnica de Val\u00e8ncia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,10]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Medicinal Chemistry: A biochemical approach","author":"Nogrady T.","year":"1988"},{"key":"e_1_2_7_3_1","unstructured":"Oyola R.(2001)Design construction and use of a nanosecond laser transient absorption spectrokinetic system for the study of the photochemical and photophysical properties of relevant biological molecules: dTpA dApT and tricyclic antidepressive drugs. 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