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Although ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) radiation is a proven risk factor for skin melanoma, the role of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> light in the etiology of uveal melanoma is still contradictory. We have compared epidemiological and genetic evidences of the potential role of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> radiation in uveal melanoma with data on cutaneous melanoma. Even though frequently mutated genes in skin melanoma (<jats:italic>e.g<\/jats:italic>. <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic>) differ from those found in uveal melanoma (<jats:italic>i.e<\/jats:italic>. <jats:italic><jats:styled-content style=\"fixed-case\">GNAQ<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">GNA<\/jats:styled-content>11<\/jats:italic>), their mutation pattern bears strong similarities. Furthermore, we provide new results showing that <jats:italic><jats:styled-content style=\"fixed-case\">RAC1<\/jats:styled-content><\/jats:italic>, a gene recently found harboring <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010hallmark mutation in skin melanoma, is also mutated in uveal melanoma. This article aims to review the work done in the last decades to understand the etiology of uveal melanoma and discuss new avenues, which shed some light on the potential role of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> exposure in uveal melanoma.<\/jats:p>","DOI":"10.1111\/php.12161","type":"journal-article","created":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T08:32:38Z","timestamp":1377333158000},"page":"15-21","source":"Crossref","is-referenced-by-count":30,"title":["Implication of ultraviolet light in the etiology of uveal melanoma: A review"],"prefix":"10.1111","volume":"90","author":[{"given":"Justin D.","family":"Mallet","sequence":"first","affiliation":[{"name":"Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice Centre de Recherche FRQS du CHU de Qu\u00e9bec H\u00f4pital du Saint\u2010Sacrement QC Canada"},{"name":"Centre LOEX de l'Universit\u00e9 Laval QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien P.","family":"Gendron","sequence":"additional","affiliation":[{"name":"Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice Centre de Recherche FRQS du CHU de Qu\u00e9bec H\u00f4pital du Saint\u2010Sacrement QC Canada"},{"name":"Centre LOEX de l'Universit\u00e9 Laval QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Catherine","family":"Drigeard Desgarnier","sequence":"additional","affiliation":[{"name":"Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice Centre de Recherche FRQS du CHU de Qu\u00e9bec H\u00f4pital du Saint\u2010Sacrement QC Canada"},{"name":"Centre LOEX de l'Universit\u00e9 Laval QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Rochette","sequence":"additional","affiliation":[{"name":"Axe M\u00e9decine R\u00e9g\u00e9n\u00e9ratrice Centre de Recherche FRQS du CHU de Qu\u00e9bec H\u00f4pital du Saint\u2010Sacrement QC Canada"},{"name":"Centre LOEX de l'Universit\u00e9 Laval QC Canada"},{"name":"D\u00e9partement d'Ophtalmologie et ORL \u2013 Chirurgie Cervico\u2010Faciale Facult\u00e9 de M\u00e9decine Universit\u00e9 Laval QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00078-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.040"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34261-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.4.5.629"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.12.1639"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.01.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.12.1684"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70213-X"},{"key":"e_1_2_7_11_1","first-page":"7","article-title":"Radiation","volume":"100","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2012","journal-title":"IARC Monogr. 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