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In this study, we showed that linear alkylbenzene sulfonates (<jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>), general anion surfactants, also generated <jats:styled-content style=\"fixed-case\">DSB<\/jats:styled-content>s with <jats:italic>\u03b3<\/jats:italic>\u2010H2<jats:styled-content style=\"fixed-case\">AX<\/jats:styled-content>, and this ability was attenuated by <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> exposure. In the human breast adenocarcinoma cell line, <jats:styled-content style=\"fixed-case\">MCF<\/jats:styled-content>\u20107, <jats:italic>\u03b3<\/jats:italic>\u2010H2<jats:styled-content style=\"fixed-case\">AX<\/jats:styled-content> was generated in a dose\u2010dependent manner immediately after cells were treated with <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>, and this was attributed to the formation of <jats:styled-content style=\"fixed-case\">DSB<\/jats:styled-content>s and was independent of cell cycle phases. The ability to generate <jats:italic>\u03b3<\/jats:italic>\u2010H2<jats:styled-content style=\"fixed-case\">AX<\/jats:styled-content> was markedly reduced in <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content> exposed to <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content> analysis revealed that <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content> were a mixture of various alkyl chain lengths, the peaks of which were detected at individual retention times. <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> evenly decreased all peaks of <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>, without migration of peaks to other retention times, which indicated that <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> may degrade the benzene ring of <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>, but did not shorten the alkyl chains. <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> is an important environmental factor in the degradation of <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content> exhibiting the ability to induce <jats:styled-content style=\"fixed-case\">DSB<\/jats:styled-content>s, the most serious type of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage.<\/jats:p>","DOI":"10.1111\/php.12268","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T11:45:07Z","timestamp":1394019907000},"page":"845-852","source":"Crossref","is-referenced-by-count":5,"title":["Phosphorylation of Histone H2<scp>AX<\/scp> Generated by Linear Alkylbenzene Sulfonates and its Suppression by <scp>UVB<\/scp> Exposure"],"prefix":"10.1111","volume":"90","author":[{"given":"Toru","family":"Kubota","sequence":"first","affiliation":[{"name":"Institute for Environmental Sciences University of Shizuoka Shizuoka 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