{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:45:12Z","timestamp":1787726712585,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:00:00Z","timestamp":1410220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Natural Science Foundation of Shandong Province, China","award":["ZR2010HM032"],"award-info":[{"award-number":["ZR2010HM032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Currently, titanium dioxide nanoparticles (TiO<jats:sub>2<\/jats:sub> <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s) have been widely used in various applications including cosmetics, food additives and biomedicine. However, there are few reports available using TiO<jats:sub>2<\/jats:sub> <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s to treat ocular diseases. Posterior capsular opacification (<jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content>) is the most frequent complication after cataract surgery, which is induced by the proliferation and migration of lens epithelial cells. Thus, inhibiting the proliferation of lens epithelial cells will efficiently reduce the occurrence of <jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content>. In this study, we investigated the effects of TiO<jats:sub>2<\/jats:sub> <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s on <jats:styled-content style=\"fixed-case\">HLE<\/jats:styled-content> B\u20103 cells with or without ultraviolet B (<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) irradiation <jats:italic>in vitro<\/jats:italic>. We found that TiO<jats:sub>2<\/jats:sub> <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s can inhibit <jats:styled-content style=\"fixed-case\">HLE<\/jats:styled-content> B\u20103 cell growth, cause the elevation of intracellular [Ca<jats:sup>2+<\/jats:sup>], produce excessive reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>), further reduce Ca<jats:sup>2+<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase activity and decrease the expression of plasma membrane calcium <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase 1 (<jats:styled-content style=\"fixed-case\">PMCA<\/jats:styled-content>1), finally disrupt the intracellular calcium homeostasis and induce cell damage. Importantly, <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation can apparently enhance these effects on <jats:styled-content style=\"fixed-case\">HLE<\/jats:styled-content> B\u20103 cells in the presence of TiO<jats:sub>2<\/jats:sub> <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s. Taken together, the generation of excessive <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> and the disruption of intracellular calcium homeostasis may be both involved in TiO<jats:sub>2<\/jats:sub> nanoparticle\u2010induced <jats:styled-content style=\"fixed-case\">HLE<\/jats:styled-content> B\u20103 cell damage under <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation.<\/jats:p>","DOI":"10.1111\/php.12322","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T16:26:59Z","timestamp":1406219219000},"page":"1324-1331","source":"Crossref","is-referenced-by-count":28,"title":["<scp>UVB<\/scp> Irradiation Enhances TiO<sub>2<\/sub> Nanoparticle\u2010induced Disruption of Calcium Homeostasis in Human Lens Epithelial Cells"],"prefix":"10.1111","volume":"90","author":[{"given":"Qiuxin","family":"Wu","sequence":"first","affiliation":[{"name":"Affiliated Eye Hospital of Shandong University of Traditional Chinese 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