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Besides being the most potent blocker of ultraviolet radiation, the role of melanin in photoprotection is complex. This is because one type of melanin called eumelanin is <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> absorbent, whereas the other, pheomelanin, is photounstable and may even promote carcinogenesis. Skin hyperpigmentation may be caused by stress or exposure to sunlight, which stimulates the release of <jats:italic>\u03b1<\/jats:italic>\u2010melanocyte stimulating hormone (<jats:italic>\u03b1<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content>) from damaged keratinocytes. Melanocortin 1 receptor (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R) is a key signaling molecule on melanocytes that responds to <jats:italic>\u03b1<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content> by inducing expression of enzymes responsible for eumelanin synthesis. Persons with red hair have mutations in the <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R causing its inactivation; this leads to a paucity of eumelanin production and makes red\u2010heads more susceptible to skin cancer. Apart from its effects on melanin production, the <jats:italic>\u03b1<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R signaling is also a potent anti\u2010inflammatory pathway and has been shown to promote antimelanoma immunity. This review will focus on the role of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R in terms of its regulation of melanogenesis and influence on the immune system with respect to skin cancer susceptibility.<\/jats:p>","DOI":"10.1111\/php.12335","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T15:47:57Z","timestamp":1408722477000},"page":"188-200","source":"Crossref","is-referenced-by-count":222,"title":["<scp>MC<\/scp>1R, Eumelanin and Pheomelanin: Their Role in Determining the Susceptibility to Skin Cancer"],"prefix":"10.1111","volume":"91","author":[{"given":"Tahseen H.","family":"Nasti","sequence":"first","affiliation":[{"name":"The Department of Dermatology University of Alabama at Birmingham School of Medicine Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Timares","sequence":"additional","affiliation":[{"name":"The Department of Dermatology University of Alabama at Birmingham School of Medicine Birmingham AL"},{"name":"The Skin Diseases Research Center University of Alabama at Birmingham School of Medicine Birmingham AL"},{"name":"The Birmingham VA Medical Center Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00751.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00226.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6649rev"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00088.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.22.723"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-862"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.20"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1548"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2003"},{"key":"e_1_2_8_12_1","first-page":"25","article-title":"The role of peroxidase in melanogenesis revisited","volume":"2","author":"Prota G.","year":"1992","journal-title":"Pigment Cell Res."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12521344"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2007.05.018"},{"key":"e_1_2_8_15_1","first-page":"582","article-title":"Le bleuissement et le noircissement des champignons","volume":"2","author":"Bourquelot E.","year":"1895","journal-title":"Comp. 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