{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:00Z","timestamp":1787015940359,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Xeroderma pigmentosum (\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    ) is a rare, recessively transmitted genetic disease characterized by increasingly marked dyspigmentation and xerosis (dryness) of sun\u2010exposed tissues, especially skin. Skin cancers characteristically develop in sun\u2010exposed sites at very much earlier ages than in the general population; these are often multiple and hundreds or even thousands may develop. Eight complementation groups have been identified. Seven groups,\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    \u2010A\u2026G, are associated with defective genes encoding proteins involved in the nucleotide excision\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    repair (\n                    <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content>\n                    ) pathway that recognizes and excises mutagenic changes induced in\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    by sunlight; the eighth group,\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    \u2010V, is associated with defective translesion synthesis (\n                    <jats:styled-content style=\"fixed-case\">TLS<\/jats:styled-content>\n                    ) bypassing such alterations. The dyspigmentation, xerosis and eventually carcinogenesis in\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    patients appear to be due to their cells\u2019 failure to respond properly to these mutagenic\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    alterations, leading to mutations in skin cells. A subset of cases, especially those in some complementation groups, may develop neurological degeneration, which may be severe. However, in most\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    patients, in the past the multiple skin cancers have led to death at an early age due to either metastases or sepsis. Using either topical 5\u2010fluorouracil or imiquimod, we have developed a protocol that effectively prevents most skin cancer development in\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    patients.\n                  <\/jats:p>","DOI":"10.1111\/php.12385","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T10:47:33Z","timestamp":1415357253000},"page":"475-483","source":"Crossref","is-referenced-by-count":39,"title":["Development of Effective Skin Cancer Treatment and Prevention in Xeroderma Pigmentosum"],"prefix":"10.1111","volume":"91","author":[{"given":"W. Clark","family":"Lambert","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and of Dermatology Rutgers University \u2013 New Jersey Medical School Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel W.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and of Dermatology Rutgers University \u2013 New Jersey Medical School Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/218652a0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.63.2.428"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690080084012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555816704"},{"key":"e_1_2_7_6_1","first-page":"411","volume-title":"DNA Repair, Mutagenesis and other Responses to DNA Damage","author":"O'Driscoll M.","year":"2013"},{"key":"e_1_2_7_7_1","first-page":"694","volume-title":"Treatment of Skin Disease: Comprehensive Therapeutic Strategies","author":"Lambert W. 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