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We have found profound variation in <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> capacity among normal individuals, between cell\u2010types and during carcinogenesis. <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> is a repair system for many types of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage, and therefore many types of genotoxic carcinogenic exposures, including ultraviolet light, products of organic combustion, metals and oxidative stress. Because <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> is intimately related to cellular metabolism, requiring components of both the <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> replicative and transcription machinery, it has a narrow range of functional viability. Thus, genes in the <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> pathway are expressed at the low levels manifested by, for example, nuclear transcription factors. As <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> activity and gene expression vary by cell\u2010type, it is inherently epigenetically regulated. Furthermore, this epigenetic modulation is disregulated during sporadic breast carcinogenesis. Loss of <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> is one basis of genomic instability, a required element in cellular transformation, and one that potentially influences response to therapy. In this study, we demonstrate differences in <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> capacity in eight adult mouse tissues, and place this result into the context of our previous work on mouse extraembryonic tissues, normal human tissues and sporadic early stage human breast cancer.<\/jats:p>","DOI":"10.1111\/php.12387","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T14:23:51Z","timestamp":1415888631000},"page":"493-500","source":"Crossref","is-referenced-by-count":7,"title":["Regulation and Disregulation of Mammalian Nucleotide Excision Repair: A Pathway to Nongermline Breast Carcinogenesis"],"prefix":"10.1111","volume":"91","author":[{"given":"Jean J.","family":"Latimer","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Nova Southeastern University Fort Lauderdale FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vongai J.","family":"Majekwana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Nova Southeastern University Fort Lauderdale FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashira R.","family":"Pab\u00f3n\u2010Pad\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Nova Southeastern University Fort Lauderdale FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manasi R.","family":"Pimpley","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Nova Southeastern University Fort Lauderdale FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Nova Southeastern University Fort Lauderdale FL"},{"name":"Public Health Program College of Osteopathic Medicine Nova Southeastern University Fort Lauderdale FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/3572686"},{"key":"e_1_2_5_3_1","first-page":"277","volume-title":"DNA Repair: A Laboratory Manual of Research Procedures","author":"Cleaver J. 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