{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:29:55Z","timestamp":1791426595848,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T00:00:00Z","timestamp":1431734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ACS","award":["RSG-13-198-01"],"award-info":[{"award-number":["RSG-13-198-01"]}]},{"name":"NIH","award":["R01-AR063630"],"award-info":[{"award-number":["R01-AR063630"]}]},{"name":"NIH","award":["AA021434"],"award-info":[{"award-number":["AA021434"]}]},{"name":"NIH","award":["AA020265"],"award-info":[{"award-number":["AA020265"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    As the most important interface between human body and external environment, skin acts as an essential barrier preventing various environmental damages, among which\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    \u2010damaging\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    radiation from the sun remains the major environmental risk factor causing various skin diseases. It has been well documented that wavelengths in the ultraviolet B (\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    ) radiation range (290\u2013320\u00a0nm) of the solar spectrum can be absorbed by skin and lead to cutaneous injury and various other deleterious effects. During process such as wound healing, the orchestrated movement of cells in a particular direction is essential and highly regulated, integrating signals controlling adhesion, polarity and the cytoskeleton. Cell adhesion and migration are modulated through both of actin and microtubule cytoskeletons. However, little was known about how\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    affects skin wound healing and migration of epidermal keratinocytes. Here, we demonstrate that\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    can delay the wound healing progress\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    with a murine model of full\u2010thickness skin wound. In addition,\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    significantly inhibited keratinocyte motility by altering focal adhesion turnover and cytoskeletal dynamics. Our results provide new insights into the etiology of\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    exposure\u2010induced skin damages.\n                  <\/jats:p>","DOI":"10.1111\/php.12462","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T09:21:51Z","timestamp":1430212911000},"page":"909-916","source":"Crossref","is-referenced-by-count":31,"title":["Ultraviolet\n                    <scp>B<\/scp>\n                    Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics"],"prefix":"10.1111","volume":"91","author":[{"given":"Han","family":"Liu","sequence":"first","affiliation":[{"name":"Ben May Department for Cancer Research The University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Yue","sequence":"additional","affiliation":[{"name":"Ben May Department for Cancer Research The University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Lei","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Medicine The University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Gou","sequence":"additional","affiliation":[{"name":"Ben May Department for Cancer Research The University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Louisville Health Science Center Louisville KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ying","family":"He","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Medicine The University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6378-3207","authenticated-orcid":false,"given":"Xiaoyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Ben May Department for Cancer Research The University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.10.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2001.01047.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.11.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.06.059"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81280-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0703-599"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.09.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0807-858"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.1.181"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.045"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.10.025"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.08.020"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00813-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310739200"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1094"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.00106.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.75"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)70714-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/377539a0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.12.033"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1262"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2369"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200105051"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30820-9"},{"key":"e_1_2_6_26_1","first-page":"136","article-title":"Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion","volume":"1","author":"Brash D. 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