{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:35:14Z","timestamp":1779402914394,"version":"3.53.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SJFE (Japanese Foundation for Research and Promotion of Endoscopy)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the feasibility of 5\u2010aminolevulinic acid (5\u2010<jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content>)\u2010mediated photodynamic diagnosis (<jats:styled-content style=\"fixed-case\">PDD<\/jats:styled-content>) in the biopsy for primary central nervous system lymphoma (<jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content>). 5\u2010<jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content> (20 mg kg<jats:sup>\u22121<\/jats:sup>) was administered orally 4 hours preoperatively. Forty\u2010one biopsies obtained under <jats:styled-content style=\"fixed-case\">PDD<\/jats:styled-content> in 47 consecutive biopsies (46 patients) that were finally pathologically diagnosed as <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content> were evaluated. Positive fluorescence was observed in 34 of those 41 biopsies (82.9%). An intraoperative pathological diagnosis (<jats:styled-content style=\"fixed-case\">IOD<\/jats:styled-content>) of suspected <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content> was made in 21 of the biopsies with positive fluorescence (61.8%). However, the eight <jats:styled-content style=\"fixed-case\">IOD<\/jats:styled-content>s in the remaining 13 biopsies (23.5%) were not correct (atypical cell, 4; high\u2010grade glioma, 1; gliosis, 1; unremarkable, 2). In those 8 biopsies, <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content> was confirmed by the final pathological diagnosis. There was no difference in the mean Mib\u20101 labeling index between the biopsies with positive fluorescence (86.5%) and those without positive fluorescence (90.0%). <jats:styled-content style=\"fixed-case\">IOD<\/jats:styled-content> was not performed in 6 biopsies; however, 5 of those biopsies (83.3%) showed positive fluorescence and were finally pathologically diagnosed as <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content>. Use of <jats:styled-content style=\"fixed-case\">PDD<\/jats:styled-content> in biopsies for patients with suspected <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content> is a reliable way of obtaining specimens of adequate quality for the final pathological diagnosis and may lead to improved diagnostic yield in the biopsy of <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/php.12510","type":"journal-article","created":{"date-parts":[[2015,8,16]],"date-time":"2015-08-16T10:01:29Z","timestamp":1439719289000},"page":"1452-1457","source":"Crossref","is-referenced-by-count":35,"title":["Photodynamic Diagnosis Using 5\u2010Aminolevulinic Acid in 41 Biopsies for Primary Central Nervous System Lymphoma"],"prefix":"10.1111","volume":"91","author":[{"given":"Tetsuya","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichiro","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zaboronok","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Akutsu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataro","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1948.5.4.0392"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70665-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0708-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9820-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-011-0991-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-014-2234-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.51.694"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.9.JNS131076"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.4.JNS102137"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-012-0374-5"},{"key":"e_1_2_8_12_1","first-page":"93","article-title":"Which intracranial lesions would be suitable for 5\u2010aminolevulenic acid\u2010induced fluorescence\u2010guided identification, localization, or resection? 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