{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:49:13Z","timestamp":1770979753861,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies have reported the association of human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) genes with susceptibility to develop actinic prurigo (<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>) in Caucasians, but there were no studies in Asian populations, including the Chinese. Our study was performed to determine if <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> is associated with susceptibility or protective <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles or haplotypes in Singaporean Chinese. All Chinese patients diagnosed with <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> at National Skin Center, Singapore, from January 2002 to April 2015 were invited to participate in the study. Clinical data and phototesting results were collated, and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> typing was performed. Among 14 patients included, 11 were male and the mean age was 49.6 (37.9\u201361.3) years. All patients did not have a family history of <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> and none had mucosal involvement, as such these clinical features differed from Caucasian <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> patients. The frequency of <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*03:01 in <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> patients was significantly higher compared to healthy controls (43% <jats:italic>vs<\/jats:italic> 16%, <jats:italic>P<\/jats:italic> = 0.022, odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 3.89). Concurrently, the frequency of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*58:01\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*03:01 haplotype was also significantly increased (25% <jats:italic>vs<\/jats:italic> 7%, <jats:italic>P<\/jats:italic> = 0.004, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.23). In conclusion, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*03:01 was associated with <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> in Singaporean Chinese patients. This novel allelic association may possibly be utilized as a biological marker to aid in the diagnosis of <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> in Chinese patients.<\/jats:p>","DOI":"10.1111\/php.12569","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T07:03:38Z","timestamp":1453273418000},"page":"355-359","source":"Crossref","is-referenced-by-count":12,"title":["Actinic Prurigo in Singaporean Chinese: A Positive Association with <scp>HLA<\/scp>\u2010<scp>DRB<\/scp>1*03:01"],"prefix":"10.1111","volume":"92","author":[{"given":"Qiping","family":"Chen","sequence":"first","affiliation":[{"name":"National Skin Center Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixin","family":"Shen","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network A*STAR Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee Kiat","family":"Heng","sequence":"additional","affiliation":[{"name":"National Skin Center Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiam Seng Colin","family":"Theng","sequence":"additional","affiliation":[{"name":"National Skin Center Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Liang","family":"Tey","sequence":"additional","affiliation":[{"name":"National Skin Center Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ee Chee","family":"Ren","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network A*STAR Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Sheng","family":"Chong","sequence":"additional","affiliation":[{"name":"National Skin Center Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70093-U"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330710207"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70144-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70150-G"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12343141"},{"key":"e_1_2_6_7_1","first-page":"65","article-title":"HLA\u2010DR4 B1 0407 \u2010 Strong association with actinic prurigo in Ireland","volume":"135","author":"O'Reilly F. 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